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Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats

BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extrac...

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Autores principales: Arzi, Ardeshir, Ghorbanzadeh, Behnam, Nazari Khorasgani, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: DocS 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941882/
https://www.ncbi.nlm.nih.gov/pubmed/24624180
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author Arzi, Ardeshir
Ghorbanzadeh, Behnam
Nazari Khorasgani, Zahra
author_facet Arzi, Ardeshir
Ghorbanzadeh, Behnam
Nazari Khorasgani, Zahra
author_sort Arzi, Ardeshir
collection PubMed
description BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extract. MATERIALS AND METHODS: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. RESULTS: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. CONCLUSIONS: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways.
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spelling pubmed-39418822014-03-12 Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats Arzi, Ardeshir Ghorbanzadeh, Behnam Nazari Khorasgani, Zahra Jundishapur J Nat Pharm Prod Research Article BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extract. MATERIALS AND METHODS: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. RESULTS: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. CONCLUSIONS: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways. DocS 2013-02-13 2013 /pmc/articles/PMC3941882/ /pubmed/24624180 Text en Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Arzi, Ardeshir
Ghorbanzadeh, Behnam
Nazari Khorasgani, Zahra
Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title_full Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title_fullStr Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title_full_unstemmed Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title_short Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
title_sort antinociceptive effect of hydroalcoholic extract of iranian green tea in the formalin test in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941882/
https://www.ncbi.nlm.nih.gov/pubmed/24624180
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