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Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats
BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extrac...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
DocS
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941882/ https://www.ncbi.nlm.nih.gov/pubmed/24624180 |
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author | Arzi, Ardeshir Ghorbanzadeh, Behnam Nazari Khorasgani, Zahra |
author_facet | Arzi, Ardeshir Ghorbanzadeh, Behnam Nazari Khorasgani, Zahra |
author_sort | Arzi, Ardeshir |
collection | PubMed |
description | BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extract. MATERIALS AND METHODS: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. RESULTS: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. CONCLUSIONS: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways. |
format | Online Article Text |
id | pubmed-3941882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | DocS |
record_format | MEDLINE/PubMed |
spelling | pubmed-39418822014-03-12 Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats Arzi, Ardeshir Ghorbanzadeh, Behnam Nazari Khorasgani, Zahra Jundishapur J Nat Pharm Prod Research Article BACKGROUND: Tea (Camellia sinensis) has been utilised, since time immemorial, as a beverage possessing encouraging health benefits. Little scientific evidence exists in literature on the effect of this plant on pain. OBJECTIVES: To investigate the antinociceptive activity of Iranian green tea extract. MATERIALS AND METHODS: The hydroalcoholic extract was administered to male Wistar rats. Formalin paw test was used to evaluate the antinociceptive activity. Plant extract (25, 50, 100 and 200 mg/kg, i.p.) (n = 6 for each group) or vehicle (n = 6) was administered 30 min before the subplantar formalin injection. RESULTS: The extract caused a significant dose-related (50, 100, 200 mg /kg, i.p.) inhibition of the first phase and onset of chronic phase (200 mg /kg, i.p.) of formalin induced nociception. The results showed that the pre-treatment of rats with naloxone (1 mg/kg, i.p.) significantly (P < 0.001) reversed antinociception by Green tea extract (GTE) (200 mg/kg, i.p.) in the inflammatory phase and had no effect on phase 1. CONCLUSIONS: These results indicate that GTE produces dose-related antinociception in chemical pain model and one of its possible mechanisms involves opioid pathways. DocS 2013-02-13 2013 /pmc/articles/PMC3941882/ /pubmed/24624180 Text en Copyright © 2013, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Arzi, Ardeshir Ghorbanzadeh, Behnam Nazari Khorasgani, Zahra Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title_full | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title_fullStr | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title_full_unstemmed | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title_short | Antinociceptive Effect of Hydroalcoholic Extract of Iranian Green tea in the Formalin Test in Rats |
title_sort | antinociceptive effect of hydroalcoholic extract of iranian green tea in the formalin test in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941882/ https://www.ncbi.nlm.nih.gov/pubmed/24624180 |
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