A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

BACKGROUND: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene....

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Detalles Bibliográficos
Autores principales: Wiegand, Kimberly C, Hennessy, Bryan T, Leung, Samuel, Wang, Yemin, Ju, Zhenlin, McGahren, Mollianne, Kalloger, Steve E, Finlayson, Sarah, Stemke-Hale, Katherine, Lu, Yiling, Zhang, Fan, Anglesio, Michael S, Gilks, Blake, Mills, Gordon B, Huntsman, David G, Carey, Mark S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941949/
https://www.ncbi.nlm.nih.gov/pubmed/24559118
http://dx.doi.org/10.1186/1471-2407-14-120

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