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Early Onset Alzheimer's Disease and Oxidative Stress

Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. It is estimated that 10% of the world's population aged more than 60–65 years could currently be affected by AD, and that in the next 20 years, there could be more than 30 million people affected by this patho...

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Autores principales: Meraz-Ríos, Marco Antonio, Franco-Bocanegra, Diana, Toral Rios, Danira, Campos-Peña, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942075/
https://www.ncbi.nlm.nih.gov/pubmed/24669286
http://dx.doi.org/10.1155/2014/375968
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author Meraz-Ríos, Marco Antonio
Franco-Bocanegra, Diana
Toral Rios, Danira
Campos-Peña, Victoria
author_facet Meraz-Ríos, Marco Antonio
Franco-Bocanegra, Diana
Toral Rios, Danira
Campos-Peña, Victoria
author_sort Meraz-Ríos, Marco Antonio
collection PubMed
description Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. It is estimated that 10% of the world's population aged more than 60–65 years could currently be affected by AD, and that in the next 20 years, there could be more than 30 million people affected by this pathology. One of the great challenges in this regard is that AD is not just a scientific problem; it is associated with major psychosocial and ethical dilemmas and has a negative impact on national economies. The neurodegenerative process that occurs in AD involves a specific nervous cell dysfunction, which leads to neuronal death. Mutations in APP, PS1, and PS2 genes are causes for early onset AD. Several animal models have demonstrated that alterations in these proteins are able to induce oxidative damage, which in turn favors the development of AD. This paper provides a review of many, although not all, of the mutations present in patients with familial Alzheimer's disease and the association between some of these mutations with both oxidative damage and the development of the pathology.
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spelling pubmed-39420752014-03-25 Early Onset Alzheimer's Disease and Oxidative Stress Meraz-Ríos, Marco Antonio Franco-Bocanegra, Diana Toral Rios, Danira Campos-Peña, Victoria Oxid Med Cell Longev Review Article Alzheimer's disease (AD) is the most common cause of dementia in elderly adults. It is estimated that 10% of the world's population aged more than 60–65 years could currently be affected by AD, and that in the next 20 years, there could be more than 30 million people affected by this pathology. One of the great challenges in this regard is that AD is not just a scientific problem; it is associated with major psychosocial and ethical dilemmas and has a negative impact on national economies. The neurodegenerative process that occurs in AD involves a specific nervous cell dysfunction, which leads to neuronal death. Mutations in APP, PS1, and PS2 genes are causes for early onset AD. Several animal models have demonstrated that alterations in these proteins are able to induce oxidative damage, which in turn favors the development of AD. This paper provides a review of many, although not all, of the mutations present in patients with familial Alzheimer's disease and the association between some of these mutations with both oxidative damage and the development of the pathology. Hindawi Publishing Corporation 2014 2014-01-14 /pmc/articles/PMC3942075/ /pubmed/24669286 http://dx.doi.org/10.1155/2014/375968 Text en Copyright © 2014 Marco Antonio Meraz-Ríos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Meraz-Ríos, Marco Antonio
Franco-Bocanegra, Diana
Toral Rios, Danira
Campos-Peña, Victoria
Early Onset Alzheimer's Disease and Oxidative Stress
title Early Onset Alzheimer's Disease and Oxidative Stress
title_full Early Onset Alzheimer's Disease and Oxidative Stress
title_fullStr Early Onset Alzheimer's Disease and Oxidative Stress
title_full_unstemmed Early Onset Alzheimer's Disease and Oxidative Stress
title_short Early Onset Alzheimer's Disease and Oxidative Stress
title_sort early onset alzheimer's disease and oxidative stress
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942075/
https://www.ncbi.nlm.nih.gov/pubmed/24669286
http://dx.doi.org/10.1155/2014/375968
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