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Antitumor Effects of a Novel Chromosome Region Maintenance 1 (CRM1) Inhibitor on Non-Small Cell Lung Cancer Cells In Vitro and in Mouse Tumor Xenografts

BACKGROUND: Chromosome Region Maintenance 1 (CRM1) is a nuclear exporter and its inhibitor has anti-tumor activity in various cancers. This study assessed the therapeutic efficiency of the novel CRM1 inhibitor KPT-185 on non-small cell lung cancer (NSCLC). METHODS: NSCLC cell lines were treated with...

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Detalles Bibliográficos
Autores principales: Wang, Shuai, Han, Xiaohong, Wang, Jianfei, Yao, Jiarui, Shi, Yuankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942386/
https://www.ncbi.nlm.nih.gov/pubmed/24595136
http://dx.doi.org/10.1371/journal.pone.0089848

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