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Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China

BACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and...

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Autores principales: Ji, Hong, Gu, Qin, Chen, Li-ling, Xu, Ke, Ling, Xia, Bao, Chang-jun, Tang, Fen-yang, Qi, Xian, Wu, Ying-qiu, Ai, Jing, Shen, Gu-yu, Dong, Dan-jiang, Yu, Hui-yan, Huang, Mao, Cao, Quan, Xu, Ying, Zhao, Wei, Xu, Yang-ting, Xia, Yu, Chen, Shan-hui, Yang, Gen-lin, Gu, Cai-ling, Xie, Guo-xiang, Zhu, Ye-fei, Zhu, Feng-cai, Zhou, Ming-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942409/
https://www.ncbi.nlm.nih.gov/pubmed/24595034
http://dx.doi.org/10.1371/journal.pone.0089581
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author Ji, Hong
Gu, Qin
Chen, Li-ling
Xu, Ke
Ling, Xia
Bao, Chang-jun
Tang, Fen-yang
Qi, Xian
Wu, Ying-qiu
Ai, Jing
Shen, Gu-yu
Dong, Dan-jiang
Yu, Hui-yan
Huang, Mao
Cao, Quan
Xu, Ying
Zhao, Wei
Xu, Yang-ting
Xia, Yu
Chen, Shan-hui
Yang, Gen-lin
Gu, Cai-ling
Xie, Guo-xiang
Zhu, Ye-fei
Zhu, Feng-cai
Zhou, Ming-hao
author_facet Ji, Hong
Gu, Qin
Chen, Li-ling
Xu, Ke
Ling, Xia
Bao, Chang-jun
Tang, Fen-yang
Qi, Xian
Wu, Ying-qiu
Ai, Jing
Shen, Gu-yu
Dong, Dan-jiang
Yu, Hui-yan
Huang, Mao
Cao, Quan
Xu, Ying
Zhao, Wei
Xu, Yang-ting
Xia, Yu
Chen, Shan-hui
Yang, Gen-lin
Gu, Cai-ling
Xie, Guo-xiang
Zhu, Ye-fei
Zhu, Feng-cai
Zhou, Ming-hao
author_sort Ji, Hong
collection PubMed
description BACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and August 14, 2013 in Jiangsu province were enrolled. Data were collected with a standard form. Mean or percentage was used to describe the features, and Fisher's exact test or t-test test was used to compare the differences between fatal and nonfatal cases with H7N9 virus infection. A total of 28 patients with H7N9 virus infection were identified among whom, nine (32.1%) died. The median age of fatal cases was significant higher than nonfatal cases (P<0.05). Patients with older age were more strongly associated with increased odds of death (OR = 30.0; 95% CI, 2.85–315.62). Co-morbidity with chronic lung disease and hypertension were risk factors for mortality (OR = 14.40; 95% CI, 1.30–159.52, OR = 6.67; 95% CI, 1.09–40.43, respectively). Moreover, the presence of either bilateral lung inflammation or pulmonary consolidation on chest imaging on admission was related with fatal outcome (OR = 7.00; 95%CI, 1.10–44.61). Finally, dynamic monitoring showed that lymphopenia was more significant in fatal group than in nonfatal group from day 11 to week five (P<0.05). The decrease in oxygenation indexes were observed in most cases and more significantly in fatal cases after week three (P<0.05), and the value of nearly all fatal cases were below 200 mmHg during our evaluation period. CONCLUSIONS: Among cases with H7N9 virus infection, increased age accompanied by co-morbidities was the risk of death. The severity of lung infection at admission, the persistence of lymphocytopenia, and the extended duration of lower oxygenation index all contributed to worsened outcomes of patients with H7N9 virus infection.
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spelling pubmed-39424092014-03-06 Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China Ji, Hong Gu, Qin Chen, Li-ling Xu, Ke Ling, Xia Bao, Chang-jun Tang, Fen-yang Qi, Xian Wu, Ying-qiu Ai, Jing Shen, Gu-yu Dong, Dan-jiang Yu, Hui-yan Huang, Mao Cao, Quan Xu, Ying Zhao, Wei Xu, Yang-ting Xia, Yu Chen, Shan-hui Yang, Gen-lin Gu, Cai-ling Xie, Guo-xiang Zhu, Ye-fei Zhu, Feng-cai Zhou, Ming-hao PLoS One Research Article BACKGROUND: A novel avian influenza A (H7N9) virus has caused great morbidity as well as mortality since its emergence in Eastern China in February 2013. However, the possible risk factors for death are not yet fully known. METHODS AND FINDINGS: Patients with H7N9 virus infection between March 1 and August 14, 2013 in Jiangsu province were enrolled. Data were collected with a standard form. Mean or percentage was used to describe the features, and Fisher's exact test or t-test test was used to compare the differences between fatal and nonfatal cases with H7N9 virus infection. A total of 28 patients with H7N9 virus infection were identified among whom, nine (32.1%) died. The median age of fatal cases was significant higher than nonfatal cases (P<0.05). Patients with older age were more strongly associated with increased odds of death (OR = 30.0; 95% CI, 2.85–315.62). Co-morbidity with chronic lung disease and hypertension were risk factors for mortality (OR = 14.40; 95% CI, 1.30–159.52, OR = 6.67; 95% CI, 1.09–40.43, respectively). Moreover, the presence of either bilateral lung inflammation or pulmonary consolidation on chest imaging on admission was related with fatal outcome (OR = 7.00; 95%CI, 1.10–44.61). Finally, dynamic monitoring showed that lymphopenia was more significant in fatal group than in nonfatal group from day 11 to week five (P<0.05). The decrease in oxygenation indexes were observed in most cases and more significantly in fatal cases after week three (P<0.05), and the value of nearly all fatal cases were below 200 mmHg during our evaluation period. CONCLUSIONS: Among cases with H7N9 virus infection, increased age accompanied by co-morbidities was the risk of death. The severity of lung infection at admission, the persistence of lymphocytopenia, and the extended duration of lower oxygenation index all contributed to worsened outcomes of patients with H7N9 virus infection. Public Library of Science 2014-03-04 /pmc/articles/PMC3942409/ /pubmed/24595034 http://dx.doi.org/10.1371/journal.pone.0089581 Text en © 2014 Ji et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ji, Hong
Gu, Qin
Chen, Li-ling
Xu, Ke
Ling, Xia
Bao, Chang-jun
Tang, Fen-yang
Qi, Xian
Wu, Ying-qiu
Ai, Jing
Shen, Gu-yu
Dong, Dan-jiang
Yu, Hui-yan
Huang, Mao
Cao, Quan
Xu, Ying
Zhao, Wei
Xu, Yang-ting
Xia, Yu
Chen, Shan-hui
Yang, Gen-lin
Gu, Cai-ling
Xie, Guo-xiang
Zhu, Ye-fei
Zhu, Feng-cai
Zhou, Ming-hao
Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title_full Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title_fullStr Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title_full_unstemmed Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title_short Epidemiological and Clinical Characteristics and Risk Factors for Death of Patients with Avian Influenza A H7N9 Virus Infection from Jiangsu Province, Eastern China
title_sort epidemiological and clinical characteristics and risk factors for death of patients with avian influenza a h7n9 virus infection from jiangsu province, eastern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942409/
https://www.ncbi.nlm.nih.gov/pubmed/24595034
http://dx.doi.org/10.1371/journal.pone.0089581
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