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Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

Bioenergetic abnormalities and metabolic dysfunction occur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs early in ALS pathophysiology linked to different ALS genes remains unclear. Here, we investigated AMP-activated protein k...

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Detalles Bibliográficos
Autores principales:	Perera, Nirma D., Sheean, Rebecca K., Scott, John W., Kemp, Bruce E., Horne, Malcolm K., Turner, Bradley J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942426/ https://www.ncbi.nlm.nih.gov/pubmed/24595038 http://dx.doi.org/10.1371/journal.pone.0090449

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