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Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins

BACKGROUND: Trans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25–50% of Alzheimer's Disease (AD) cases. These abnormal protein inclusions are composed...

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Detalles Bibliográficos
Autores principales:	Carlomagno, Yari, Zhang, Yongjie, Davis, Mary, Lin, Wen-Lang, Cook, Casey, Dunmore, Judy, Tay, William, Menkosky, Kyle, Cao, Xiangkun, Petrucelli, Leonard, DeTure, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942448/ https://www.ncbi.nlm.nih.gov/pubmed/24595055 http://dx.doi.org/10.1371/journal.pone.0090452

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