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The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ∼40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent...

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Detalles Bibliográficos
Autores principales:	Evans, Sian E., Goult, Benjamin T., Fairall, Louise, Jamieson, Andrew G., Ko Ferrigno, Paul, Ford, Robert, Schwabe, John W. R., Wagner, Simon D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942486/ https://www.ncbi.nlm.nih.gov/pubmed/24595451 http://dx.doi.org/10.1371/journal.pone.0090889

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