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Altered Endoribonuclease Activity of Apurinic/Apyrimidinic Endonuclease 1 Variants Identified in the Human Population

Apurinic/apyrimidinic endonuclease 1 (APE1) is the major mammalian enzyme in the DNA base excision repair pathway and cleaves the DNA phosphodiester backbone immediately 5′ to abasic sites. APE1 also has 3′-5′ DNA exonuclease and 3′ DNA phosphodiesterase activities, and regulates transcription facto...

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Detalles Bibliográficos
Autores principales:	Kim, Wan Cheol, Ma, Conan, Li, Wai-Ming, Chohan, Manbir, Wilson III, David M., Lee, Chow H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942487/ https://www.ncbi.nlm.nih.gov/pubmed/24595156 http://dx.doi.org/10.1371/journal.pone.0090837

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