NF-κB Activation in T Helper 17 Cell Differentiation

CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell diff...

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Detalles Bibliográficos
Autores principales: Park, Sang-Heon, Cho, Gabi, Park, Sung-Gyoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942503/
https://www.ncbi.nlm.nih.gov/pubmed/24605076
http://dx.doi.org/10.4110/in.2014.14.1.14
Descripción
Sumario:CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation.

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