NF-κB Activation in T Helper 17 Cell Differentiation

CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell diff...

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Detalles Bibliográficos
Autores principales: Park, Sang-Heon, Cho, Gabi, Park, Sung-Gyoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942503/
https://www.ncbi.nlm.nih.gov/pubmed/24605076
http://dx.doi.org/10.4110/in.2014.14.1.14
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author Park, Sang-Heon
Cho, Gabi
Park, Sung-Gyoo
author_facet Park, Sang-Heon
Cho, Gabi
Park, Sung-Gyoo
author_sort Park, Sang-Heon
collection PubMed
description CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation.
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spelling pubmed-39425032014-03-06 NF-κB Activation in T Helper 17 Cell Differentiation Park, Sang-Heon Cho, Gabi Park, Sung-Gyoo Immune Netw CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differentiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation. The Korean Association of Immunologists 2014-02 2014-02-21 /pmc/articles/PMC3942503/ /pubmed/24605076 http://dx.doi.org/10.4110/in.2014.14.1.14 Text en Copyright © 2014 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Park, Sang-Heon
Cho, Gabi
Park, Sung-Gyoo
NF-κB Activation in T Helper 17 Cell Differentiation
title NF-κB Activation in T Helper 17 Cell Differentiation
title_full NF-κB Activation in T Helper 17 Cell Differentiation
title_fullStr NF-κB Activation in T Helper 17 Cell Differentiation
title_full_unstemmed NF-κB Activation in T Helper 17 Cell Differentiation
title_short NF-κB Activation in T Helper 17 Cell Differentiation
title_sort nf-κb activation in t helper 17 cell differentiation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942503/
https://www.ncbi.nlm.nih.gov/pubmed/24605076
http://dx.doi.org/10.4110/in.2014.14.1.14
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AT chogabi nfkbactivationinthelper17celldifferentiation
AT parksunggyoo nfkbactivationinthelper17celldifferentiation

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