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Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs

OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders wer...

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Autores principales: Yoshimura, Reiji, Kishi, Taro, Hori, Hikaru, Katsuki, Asuka, Sugita-Ikenouchi, Atsuko, Umene-Nakano, Wakako, Atake, Kiyokazu, Iwata, Nakao, Nakamura, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942556/
https://www.ncbi.nlm.nih.gov/pubmed/24605128
http://dx.doi.org/10.4306/pi.2014.11.1.84
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author Yoshimura, Reiji
Kishi, Taro
Hori, Hikaru
Katsuki, Asuka
Sugita-Ikenouchi, Atsuko
Umene-Nakano, Wakako
Atake, Kiyokazu
Iwata, Nakao
Nakamura, Jun
author_facet Yoshimura, Reiji
Kishi, Taro
Hori, Hikaru
Katsuki, Asuka
Sugita-Ikenouchi, Atsuko
Umene-Nakano, Wakako
Atake, Kiyokazu
Iwata, Nakao
Nakamura, Jun
author_sort Yoshimura, Reiji
collection PubMed
description OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4±15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8.
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spelling pubmed-39425562014-03-06 Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs Yoshimura, Reiji Kishi, Taro Hori, Hikaru Katsuki, Asuka Sugita-Ikenouchi, Atsuko Umene-Nakano, Wakako Atake, Kiyokazu Iwata, Nakao Nakamura, Jun Psychiatry Investig OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4±15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8. Korean Neuropsychiatric Association 2014-01 2014-01-21 /pmc/articles/PMC3942556/ /pubmed/24605128 http://dx.doi.org/10.4306/pi.2014.11.1.84 Text en Copyright © 2014 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Yoshimura, Reiji
Kishi, Taro
Hori, Hikaru
Katsuki, Asuka
Sugita-Ikenouchi, Atsuko
Umene-Nakano, Wakako
Atake, Kiyokazu
Iwata, Nakao
Nakamura, Jun
Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title_full Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title_fullStr Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title_full_unstemmed Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title_short Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
title_sort serum levels of brain-derived neurotrophic factor at 4 weeks and response to treatment with ssris
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942556/
https://www.ncbi.nlm.nih.gov/pubmed/24605128
http://dx.doi.org/10.4306/pi.2014.11.1.84
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