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Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs
OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders wer...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neuropsychiatric Association
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942556/ https://www.ncbi.nlm.nih.gov/pubmed/24605128 http://dx.doi.org/10.4306/pi.2014.11.1.84 |
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author | Yoshimura, Reiji Kishi, Taro Hori, Hikaru Katsuki, Asuka Sugita-Ikenouchi, Atsuko Umene-Nakano, Wakako Atake, Kiyokazu Iwata, Nakao Nakamura, Jun |
author_facet | Yoshimura, Reiji Kishi, Taro Hori, Hikaru Katsuki, Asuka Sugita-Ikenouchi, Atsuko Umene-Nakano, Wakako Atake, Kiyokazu Iwata, Nakao Nakamura, Jun |
author_sort | Yoshimura, Reiji |
collection | PubMed |
description | OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4±15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8. |
format | Online Article Text |
id | pubmed-3942556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-39425562014-03-06 Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs Yoshimura, Reiji Kishi, Taro Hori, Hikaru Katsuki, Asuka Sugita-Ikenouchi, Atsuko Umene-Nakano, Wakako Atake, Kiyokazu Iwata, Nakao Nakamura, Jun Psychiatry Investig OBJECTIVE: It is important to predict a response to an antidepressant in early time after starting the antidepressant. We previously reported that serum brain-derived neurotrophic factor (BDNF) levels in responders to treatment with antidepressants were increased, whereas, those in nonresponders were not. Therefore, we hypothesized that the changes in serum levels of BDNF from baseline (T0) to 4 weeks (T4) after treatment with selective serotonin reuptake inhibitors (SSRIs) predict the response to the treatment at 8 weeks (T8) in depressed patients. To confirm the hypothesis, we measured serum BDNF at T0, T4, and T8 during the treatment with SSRIs (paroxetine, sertraline, and fluvoxamine). METHODS: One hundred fifty patients (M/F; 51/99, age; 50.4±15.1 years) met major depressive disorder (MDD) using by DSM-IV-TR enrolled in the present study. We measured serum BDNF concentrations at T0, T4, and T8 in patients with MDD treated with SSRIs. RESULTS: The changes in serum BDNF, age, sex, dose of SSRIs, and HAMD-17 score did not predict the response to SSRIs at T8. CONCLUSION: These results suggest that the changes in serum BDNF levels from T0 to T4 could not predict the subsequent responses to SSRIs at T8. Korean Neuropsychiatric Association 2014-01 2014-01-21 /pmc/articles/PMC3942556/ /pubmed/24605128 http://dx.doi.org/10.4306/pi.2014.11.1.84 Text en Copyright © 2014 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Yoshimura, Reiji Kishi, Taro Hori, Hikaru Katsuki, Asuka Sugita-Ikenouchi, Atsuko Umene-Nakano, Wakako Atake, Kiyokazu Iwata, Nakao Nakamura, Jun Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title | Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title_full | Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title_fullStr | Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title_full_unstemmed | Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title_short | Serum Levels of Brain-Derived Neurotrophic Factor at 4 Weeks and Response to Treatment with SSRIs |
title_sort | serum levels of brain-derived neurotrophic factor at 4 weeks and response to treatment with ssris |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942556/ https://www.ncbi.nlm.nih.gov/pubmed/24605128 http://dx.doi.org/10.4306/pi.2014.11.1.84 |
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