Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South Eas...

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Autores principales: Bane, Vaishali, Lehane, Mary, Dikshit, Madhurima, O’Riordan, Alan, Furey, Ambrose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942760/
https://www.ncbi.nlm.nih.gov/pubmed/24566728
http://dx.doi.org/10.3390/toxins6020693
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author Bane, Vaishali
Lehane, Mary
Dikshit, Madhurima
O’Riordan, Alan
Furey, Ambrose
author_facet Bane, Vaishali
Lehane, Mary
Dikshit, Madhurima
O’Riordan, Alan
Furey, Ambrose
author_sort Bane, Vaishali
collection PubMed
description Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.
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spelling pubmed-39427602014-03-05 Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection Bane, Vaishali Lehane, Mary Dikshit, Madhurima O’Riordan, Alan Furey, Ambrose Toxins (Basel) Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection. MDPI 2014-02-21 /pmc/articles/PMC3942760/ /pubmed/24566728 http://dx.doi.org/10.3390/toxins6020693 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Bane, Vaishali
Lehane, Mary
Dikshit, Madhurima
O’Riordan, Alan
Furey, Ambrose
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title_full Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title_fullStr Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title_full_unstemmed Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title_short Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
title_sort tetrodotoxin: chemistry, toxicity, source, distribution and detection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942760/
https://www.ncbi.nlm.nih.gov/pubmed/24566728
http://dx.doi.org/10.3390/toxins6020693
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AT oriordanalan tetrodotoxinchemistrytoxicitysourcedistributionanddetection
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