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Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study

BACKGROUND: The purpose of this study was to evaluate the efficacy and feasibility of carbon ion radiotherapy (CIRT) for oligo-recurrent lung tumors from colorectal cancer (CRC). METHODS: From May 1997 to October 2012, 34 consecutive patients with oligo-recurrent pulmonary metastases from CRC were t...

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Autores principales: Takahashi, Wataru, Nakajima, Mio, Yamamoto, Naoyoshi, Yamada, Shigeru, Yamashita, Hideomi, Nakagawa, Keiichi, Tsuji, Hiroshi, Kamada, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942770/
https://www.ncbi.nlm.nih.gov/pubmed/24581481
http://dx.doi.org/10.1186/1748-717X-9-68
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author Takahashi, Wataru
Nakajima, Mio
Yamamoto, Naoyoshi
Yamada, Shigeru
Yamashita, Hideomi
Nakagawa, Keiichi
Tsuji, Hiroshi
Kamada, Tadashi
author_facet Takahashi, Wataru
Nakajima, Mio
Yamamoto, Naoyoshi
Yamada, Shigeru
Yamashita, Hideomi
Nakagawa, Keiichi
Tsuji, Hiroshi
Kamada, Tadashi
author_sort Takahashi, Wataru
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the efficacy and feasibility of carbon ion radiotherapy (CIRT) for oligo-recurrent lung tumors from colorectal cancer (CRC). METHODS: From May 1997 to October 2012, 34 consecutive patients with oligo-recurrent pulmonary metastases from CRC were treated with CIRT. The patients were not surgical candidates for medical reasons or patient refusal. Using a respiratory-gated technique, carbon ion therapy was delivered with curative intent using 4 coplanar beam angles. A median dose of 60 GyE (range, 44–64.8 GyE) was delivered to the planning target volume (PTV), with a median daily dose of 15 GyE (range, 3.6–44 GyE). Treatment outcome was analyzed in terms of local control rate (LCR), survival rate, and treatment-related complications. RESULTS: In total, 34 patients with 44 oligo-recurrent pulmonary lesions were treated with CIRT. Median follow-up period was 23.7 months. The 2- and 3-year actuarial LCRs of the treated patients were 85.4% ± 6.2% and 85.4% ± 6.2%, respectively. Overall survival was 65.1% ± 9.5% at 2 years, and 50.1% ± 10.5% at 3 years. Although survival rates were relatively worse in the subsets of patients aged < 63 years or with early metastasis (< 36 months after resection of primary site), these factors were not significantly correlated with overall survival (P = 0.13 and 0.19, respectively). All treatment-related complications were self-limited, without any grade 3–5 toxicity. CONCLUSIONS: CIRT is one of the most effective nonsurgical treatments for colorectal lung metastases, which are relatively resistant to stereotactic body radiotherapy. CIRT is considered to be the least invasive approach even in patients who have undergone repeated prior thoracic metastasectomies.
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spelling pubmed-39427702014-03-06 Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study Takahashi, Wataru Nakajima, Mio Yamamoto, Naoyoshi Yamada, Shigeru Yamashita, Hideomi Nakagawa, Keiichi Tsuji, Hiroshi Kamada, Tadashi Radiat Oncol Research BACKGROUND: The purpose of this study was to evaluate the efficacy and feasibility of carbon ion radiotherapy (CIRT) for oligo-recurrent lung tumors from colorectal cancer (CRC). METHODS: From May 1997 to October 2012, 34 consecutive patients with oligo-recurrent pulmonary metastases from CRC were treated with CIRT. The patients were not surgical candidates for medical reasons or patient refusal. Using a respiratory-gated technique, carbon ion therapy was delivered with curative intent using 4 coplanar beam angles. A median dose of 60 GyE (range, 44–64.8 GyE) was delivered to the planning target volume (PTV), with a median daily dose of 15 GyE (range, 3.6–44 GyE). Treatment outcome was analyzed in terms of local control rate (LCR), survival rate, and treatment-related complications. RESULTS: In total, 34 patients with 44 oligo-recurrent pulmonary lesions were treated with CIRT. Median follow-up period was 23.7 months. The 2- and 3-year actuarial LCRs of the treated patients were 85.4% ± 6.2% and 85.4% ± 6.2%, respectively. Overall survival was 65.1% ± 9.5% at 2 years, and 50.1% ± 10.5% at 3 years. Although survival rates were relatively worse in the subsets of patients aged < 63 years or with early metastasis (< 36 months after resection of primary site), these factors were not significantly correlated with overall survival (P = 0.13 and 0.19, respectively). All treatment-related complications were self-limited, without any grade 3–5 toxicity. CONCLUSIONS: CIRT is one of the most effective nonsurgical treatments for colorectal lung metastases, which are relatively resistant to stereotactic body radiotherapy. CIRT is considered to be the least invasive approach even in patients who have undergone repeated prior thoracic metastasectomies. BioMed Central 2014-03-01 /pmc/articles/PMC3942770/ /pubmed/24581481 http://dx.doi.org/10.1186/1748-717X-9-68 Text en Copyright © 2014 Takahashi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Takahashi, Wataru
Nakajima, Mio
Yamamoto, Naoyoshi
Yamada, Shigeru
Yamashita, Hideomi
Nakagawa, Keiichi
Tsuji, Hiroshi
Kamada, Tadashi
Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title_full Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title_fullStr Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title_full_unstemmed Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title_short Carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
title_sort carbon ion radiotherapy for oligo-recurrent lung metastases from colorectal cancer: a feasibility study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942770/
https://www.ncbi.nlm.nih.gov/pubmed/24581481
http://dx.doi.org/10.1186/1748-717X-9-68
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