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Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii

Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heve...

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Autores principales: Yeh, Pen-Ho, Shieh, Yun-Dar, Hsu, Li-Chun, Kuo, Li-Ming Yang, Lin, Jhih-Hu, Liaw, Chia-Ching, Kuo, Yao-Haur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942899/
https://www.ncbi.nlm.nih.gov/pubmed/24716136
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author Yeh, Pen-Ho
Shieh, Yun-Dar
Hsu, Li-Chun
Kuo, Li-Ming Yang
Lin, Jhih-Hu
Liaw, Chia-Ching
Kuo, Yao-Haur
author_facet Yeh, Pen-Ho
Shieh, Yun-Dar
Hsu, Li-Chun
Kuo, Li-Ming Yang
Lin, Jhih-Hu
Liaw, Chia-Ching
Kuo, Yao-Haur
author_sort Yeh, Pen-Ho
collection PubMed
description Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED(50) ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
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spelling pubmed-39428992014-04-08 Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii Yeh, Pen-Ho Shieh, Yun-Dar Hsu, Li-Chun Kuo, Li-Ming Yang Lin, Jhih-Hu Liaw, Chia-Ching Kuo, Yao-Haur J Tradit Complement Med Original Article Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED(50) ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3942899/ /pubmed/24716136 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yeh, Pen-Ho
Shieh, Yun-Dar
Hsu, Li-Chun
Kuo, Li-Ming Yang
Lin, Jhih-Hu
Liaw, Chia-Ching
Kuo, Yao-Haur
Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title_full Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title_fullStr Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title_full_unstemmed Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title_short Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
title_sort naturally occurring cytotoxic [3′→8″]-biflavonoids from podocarpus nakaii
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942899/
https://www.ncbi.nlm.nih.gov/pubmed/24716136
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