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Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heve...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942899/ https://www.ncbi.nlm.nih.gov/pubmed/24716136 |
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author | Yeh, Pen-Ho Shieh, Yun-Dar Hsu, Li-Chun Kuo, Li-Ming Yang Lin, Jhih-Hu Liaw, Chia-Ching Kuo, Yao-Haur |
author_facet | Yeh, Pen-Ho Shieh, Yun-Dar Hsu, Li-Chun Kuo, Li-Ming Yang Lin, Jhih-Hu Liaw, Chia-Ching Kuo, Yao-Haur |
author_sort | Yeh, Pen-Ho |
collection | PubMed |
description | Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED(50) ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity. |
format | Online Article Text |
id | pubmed-3942899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39428992014-04-08 Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii Yeh, Pen-Ho Shieh, Yun-Dar Hsu, Li-Chun Kuo, Li-Ming Yang Lin, Jhih-Hu Liaw, Chia-Ching Kuo, Yao-Haur J Tradit Complement Med Original Article Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED(50) ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3942899/ /pubmed/24716136 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yeh, Pen-Ho Shieh, Yun-Dar Hsu, Li-Chun Kuo, Li-Ming Yang Lin, Jhih-Hu Liaw, Chia-Ching Kuo, Yao-Haur Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title | Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title_full | Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title_fullStr | Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title_full_unstemmed | Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title_short | Naturally Occurring Cytotoxic [3′→8″]-Biflavonoids from Podocarpus nakaii |
title_sort | naturally occurring cytotoxic [3′→8″]-biflavonoids from podocarpus nakaii |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942899/ https://www.ncbi.nlm.nih.gov/pubmed/24716136 |
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