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Immunoprophylactic Effects of Administering Honeybee (Apis melifera) Venom Spray against Salmonella Gallinarum in Broiler Chicks
Antibiotics continue to be used as growth promoters in the poultry industry. Honeybee (Apis melifera) venom (HBV) possesses a number of beneficial biological activities, particularly for regulating the immune system. The aim of the present study was to evaluate the immunoprophylactic effects of HBV...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942925/ https://www.ncbi.nlm.nih.gov/pubmed/23719751 http://dx.doi.org/10.1292/jvms.13-0045 |
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author | JUNG, Bock-Gie LEE, Jin-A PARK, Seong-Beom HYUN, Pung-Mi PARK, Jin-Kyu SUH, Guk-Hyun LEE, Bong-Joo |
author_facet | JUNG, Bock-Gie LEE, Jin-A PARK, Seong-Beom HYUN, Pung-Mi PARK, Jin-Kyu SUH, Guk-Hyun LEE, Bong-Joo |
author_sort | JUNG, Bock-Gie |
collection | PubMed |
description | Antibiotics continue to be used as growth promoters in the poultry industry. Honeybee (Apis melifera) venom (HBV) possesses a number of beneficial biological activities, particularly for regulating the immune system. The aim of the present study was to evaluate the immunoprophylactic effects of HBV against Salmonella Gallinarum in broiler chicks as an initial step towards developing eco-friendly alternatives to reduce antibiotic use. HBV was administered using a spray technique. HBV improved body weight gain, particularly in the presence of infection. Moreover, HBV enhanced antibody production activity against formalin-killed S. Gallinarum. The CD4(+):CD8(+) T lymphocyte ratio, relative mRNA expression levels of interleukin-18 and interferon-γ, and serum lysozyme activity also increased following HBV administration before the infection period as well as during infection. HBV reinforced bacterial clearance and increased survivability against S. Gallinarum. Corresponding pathological analyses demonstrated that the HBV-sprayed group displayed mild and less severe abnormal changes compared with those in the control group. It was presumed that the prophylactic effects of HBV against S. Gallinarum were associated with its non-specific immune response stimulating activity. Thus, HBV may provide an alternative to reduce antibiotic use in the poultry industry. |
format | Online Article Text |
id | pubmed-3942925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39429252014-04-22 Immunoprophylactic Effects of Administering Honeybee (Apis melifera) Venom Spray against Salmonella Gallinarum in Broiler Chicks JUNG, Bock-Gie LEE, Jin-A PARK, Seong-Beom HYUN, Pung-Mi PARK, Jin-Kyu SUH, Guk-Hyun LEE, Bong-Joo J Vet Med Sci Immunology Antibiotics continue to be used as growth promoters in the poultry industry. Honeybee (Apis melifera) venom (HBV) possesses a number of beneficial biological activities, particularly for regulating the immune system. The aim of the present study was to evaluate the immunoprophylactic effects of HBV against Salmonella Gallinarum in broiler chicks as an initial step towards developing eco-friendly alternatives to reduce antibiotic use. HBV was administered using a spray technique. HBV improved body weight gain, particularly in the presence of infection. Moreover, HBV enhanced antibody production activity against formalin-killed S. Gallinarum. The CD4(+):CD8(+) T lymphocyte ratio, relative mRNA expression levels of interleukin-18 and interferon-γ, and serum lysozyme activity also increased following HBV administration before the infection period as well as during infection. HBV reinforced bacterial clearance and increased survivability against S. Gallinarum. Corresponding pathological analyses demonstrated that the HBV-sprayed group displayed mild and less severe abnormal changes compared with those in the control group. It was presumed that the prophylactic effects of HBV against S. Gallinarum were associated with its non-specific immune response stimulating activity. Thus, HBV may provide an alternative to reduce antibiotic use in the poultry industry. The Japanese Society of Veterinary Science 2013-05-30 2013-10 /pmc/articles/PMC3942925/ /pubmed/23719751 http://dx.doi.org/10.1292/jvms.13-0045 Text en ©2013 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Immunology JUNG, Bock-Gie LEE, Jin-A PARK, Seong-Beom HYUN, Pung-Mi PARK, Jin-Kyu SUH, Guk-Hyun LEE, Bong-Joo Immunoprophylactic Effects of Administering Honeybee (Apis melifera) Venom Spray against Salmonella Gallinarum in Broiler Chicks |
title | Immunoprophylactic Effects of Administering Honeybee (Apis
melifera) Venom Spray against Salmonella
Gallinarum in Broiler Chicks |
title_full | Immunoprophylactic Effects of Administering Honeybee (Apis
melifera) Venom Spray against Salmonella
Gallinarum in Broiler Chicks |
title_fullStr | Immunoprophylactic Effects of Administering Honeybee (Apis
melifera) Venom Spray against Salmonella
Gallinarum in Broiler Chicks |
title_full_unstemmed | Immunoprophylactic Effects of Administering Honeybee (Apis
melifera) Venom Spray against Salmonella
Gallinarum in Broiler Chicks |
title_short | Immunoprophylactic Effects of Administering Honeybee (Apis
melifera) Venom Spray against Salmonella
Gallinarum in Broiler Chicks |
title_sort | immunoprophylactic effects of administering honeybee (apis
melifera) venom spray against salmonella
gallinarum in broiler chicks |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942925/ https://www.ncbi.nlm.nih.gov/pubmed/23719751 http://dx.doi.org/10.1292/jvms.13-0045 |
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