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Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing Meningoencephalitis in Pug Dogs
To evaluate the ability of serum glial fibrillary acidic protein (GFAP) concentration as a diagnostic marker for canine central nervous system (CNS) disorders, sera from dogs with various CNS (n=47) and non-CNS (n=56) disorders were measured for GFAP by using an ELISA kit. Healthy Beagles (n=15) and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942992/ https://www.ncbi.nlm.nih.gov/pubmed/23856761 http://dx.doi.org/10.1292/jvms.13-0252 |
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author | MIYAKE, Hizuru INOUE, Akiko TANAKA, Miho MATSUKI, Naoaki |
author_facet | MIYAKE, Hizuru INOUE, Akiko TANAKA, Miho MATSUKI, Naoaki |
author_sort | MIYAKE, Hizuru |
collection | PubMed |
description | To evaluate the ability of serum glial fibrillary acidic protein (GFAP) concentration as a diagnostic marker for canine central nervous system (CNS) disorders, sera from dogs with various CNS (n=47) and non-CNS (n=56) disorders were measured for GFAP by using an ELISA kit. Healthy Beagles (n=15) and Pug dogs (n=12) were also examined as controls. Interestingly, only Pug dogs with necrotizing meningoencephalitis (NME) showed elevated serum GFAP concentrations (<0.01 to 1.14 ng/ml), while other breeds of dogs with NME did not. Among the Pug dogs with NME, serum GFAP concentrations did not correlate with their clinical features, such as ages or survival times. Our data indicate the usefulness of serum GFAP as a novel marker for Pug dogs with NME. |
format | Online Article Text |
id | pubmed-3942992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39429922014-04-22 Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing Meningoencephalitis in Pug Dogs MIYAKE, Hizuru INOUE, Akiko TANAKA, Miho MATSUKI, Naoaki J Vet Med Sci Clinical Pathology To evaluate the ability of serum glial fibrillary acidic protein (GFAP) concentration as a diagnostic marker for canine central nervous system (CNS) disorders, sera from dogs with various CNS (n=47) and non-CNS (n=56) disorders were measured for GFAP by using an ELISA kit. Healthy Beagles (n=15) and Pug dogs (n=12) were also examined as controls. Interestingly, only Pug dogs with necrotizing meningoencephalitis (NME) showed elevated serum GFAP concentrations (<0.01 to 1.14 ng/ml), while other breeds of dogs with NME did not. Among the Pug dogs with NME, serum GFAP concentrations did not correlate with their clinical features, such as ages or survival times. Our data indicate the usefulness of serum GFAP as a novel marker for Pug dogs with NME. The Japanese Society of Veterinary Science 2013-07-12 2013-11 /pmc/articles/PMC3942992/ /pubmed/23856761 http://dx.doi.org/10.1292/jvms.13-0252 Text en ©2013 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Clinical Pathology MIYAKE, Hizuru INOUE, Akiko TANAKA, Miho MATSUKI, Naoaki Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing Meningoencephalitis in Pug Dogs |
title | Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing
Meningoencephalitis in Pug Dogs |
title_full | Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing
Meningoencephalitis in Pug Dogs |
title_fullStr | Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing
Meningoencephalitis in Pug Dogs |
title_full_unstemmed | Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing
Meningoencephalitis in Pug Dogs |
title_short | Serum Glial Fibrillary Acidic Protein as a Specific Marker for Necrotizing
Meningoencephalitis in Pug Dogs |
title_sort | serum glial fibrillary acidic protein as a specific marker for necrotizing
meningoencephalitis in pug dogs |
topic | Clinical Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942992/ https://www.ncbi.nlm.nih.gov/pubmed/23856761 http://dx.doi.org/10.1292/jvms.13-0252 |
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