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The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. M...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Shahid Beheshti University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943045/ https://www.ncbi.nlm.nih.gov/pubmed/24665311 |
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author | FALLAH, Razieh AKHAVAN KARBASI, Sedighah SHAJARI, Ahmad FROMANDI, Mostafa |
author_facet | FALLAH, Razieh AKHAVAN KARBASI, Sedighah SHAJARI, Ahmad FROMANDI, Mostafa |
author_sort | FALLAH, Razieh |
collection | PubMed |
description | OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. MATERIALS & METHODS: In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months. RESULTS: Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported. CONCLUSION: TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis. |
format | Online Article Text |
id | pubmed-3943045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Shahid Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39430452014-03-24 The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children FALLAH, Razieh AKHAVAN KARBASI, Sedighah SHAJARI, Ahmad FROMANDI, Mostafa Iran J Child Neurol Original Article OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. MATERIALS & METHODS: In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months. RESULTS: Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported. CONCLUSION: TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis. Shahid Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3943045/ /pubmed/24665311 Text en © 2013: Iranian Journal of Child Neurology This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article FALLAH, Razieh AKHAVAN KARBASI, Sedighah SHAJARI, Ahmad FROMANDI, Mostafa The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title | The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title_full | The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title_fullStr | The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title_full_unstemmed | The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title_short | The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children |
title_sort | efficacy and safety of topiramate for prophylaxis of migraine in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943045/ https://www.ncbi.nlm.nih.gov/pubmed/24665311 |
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