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The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children

OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. M...

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Autores principales: FALLAH, Razieh, AKHAVAN KARBASI, Sedighah, SHAJARI, Ahmad, FROMANDI, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943045/
https://www.ncbi.nlm.nih.gov/pubmed/24665311
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author FALLAH, Razieh
AKHAVAN KARBASI, Sedighah
SHAJARI, Ahmad
FROMANDI, Mostafa
author_facet FALLAH, Razieh
AKHAVAN KARBASI, Sedighah
SHAJARI, Ahmad
FROMANDI, Mostafa
author_sort FALLAH, Razieh
collection PubMed
description OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. MATERIALS & METHODS: In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months. RESULTS: Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported. CONCLUSION: TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis.
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spelling pubmed-39430452014-03-24 The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children FALLAH, Razieh AKHAVAN KARBASI, Sedighah SHAJARI, Ahmad FROMANDI, Mostafa Iran J Child Neurol Original Article OBJECTIVE: Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. MATERIALS & METHODS: In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months. RESULTS: Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported. CONCLUSION: TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis. Shahid Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3943045/ /pubmed/24665311 Text en © 2013: Iranian Journal of Child Neurology This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
FALLAH, Razieh
AKHAVAN KARBASI, Sedighah
SHAJARI, Ahmad
FROMANDI, Mostafa
The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title_full The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title_fullStr The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title_full_unstemmed The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title_short The Efficacy and Safety of Topiramate for Prophylaxis of Migraine in Children
title_sort efficacy and safety of topiramate for prophylaxis of migraine in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943045/
https://www.ncbi.nlm.nih.gov/pubmed/24665311
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