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Vincristine-Induced Cranial Neuropathy
Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms’ tumor, treat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shahid Beheshti University of Medical Sciences
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943062/ https://www.ncbi.nlm.nih.gov/pubmed/24665331 |
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author | TALEBIAN, Ahmad GOUDARZI, Razieh Moazam MOHAMMADZADEH, Mahdi MIRZADEH, Azadeh Sadat |
author_facet | TALEBIAN, Ahmad GOUDARZI, Razieh Moazam MOHAMMADZADEH, Mahdi MIRZADEH, Azadeh Sadat |
author_sort | TALEBIAN, Ahmad |
collection | PubMed |
description | Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms’ tumor, treated by vincristine (0.067 mg/kg/day) and dactinomycin (0.045 mg/kg/day) after surgery. Three weeks after treatment, he presented with bilateral ptosis. Neurological examination revealed bilateral ptosis with normal pupillary reflex and eye movement. He received 3.015 mg cumulative dose of vincristine before development of ptosis. Treatment with pyridoxine (150 mg/m2 p.o. BID) and pyridostigmine (3 mg/kg p.o. BID) was started as neuroprotective agents, and after 7 days the problem disappeared. The treatment continued for 6 weeks and there were no signs of ptosis or a recurrence in follow up 2 months later. |
format | Online Article Text |
id | pubmed-3943062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Shahid Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-39430622015-03-01 Vincristine-Induced Cranial Neuropathy TALEBIAN, Ahmad GOUDARZI, Razieh Moazam MOHAMMADZADEH, Mahdi MIRZADEH, Azadeh Sadat Iran J Child Neurol Case Report Vincristine (VCR) is a vinca alkaloid that is used for treatment of many malignancies. The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. Described here is the case of a 2.5-year-old boy, a known case of Wilms’ tumor, treated by vincristine (0.067 mg/kg/day) and dactinomycin (0.045 mg/kg/day) after surgery. Three weeks after treatment, he presented with bilateral ptosis. Neurological examination revealed bilateral ptosis with normal pupillary reflex and eye movement. He received 3.015 mg cumulative dose of vincristine before development of ptosis. Treatment with pyridoxine (150 mg/m2 p.o. BID) and pyridostigmine (3 mg/kg p.o. BID) was started as neuroprotective agents, and after 7 days the problem disappeared. The treatment continued for 6 weeks and there were no signs of ptosis or a recurrence in follow up 2 months later. Shahid Beheshti University of Medical Sciences 2014 /pmc/articles/PMC3943062/ /pubmed/24665331 Text en 2014: Iranian Journal of Child Neurology This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report TALEBIAN, Ahmad GOUDARZI, Razieh Moazam MOHAMMADZADEH, Mahdi MIRZADEH, Azadeh Sadat Vincristine-Induced Cranial Neuropathy |
title | Vincristine-Induced Cranial Neuropathy |
title_full | Vincristine-Induced Cranial Neuropathy |
title_fullStr | Vincristine-Induced Cranial Neuropathy |
title_full_unstemmed | Vincristine-Induced Cranial Neuropathy |
title_short | Vincristine-Induced Cranial Neuropathy |
title_sort | vincristine-induced cranial neuropathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943062/ https://www.ncbi.nlm.nih.gov/pubmed/24665331 |
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