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Paraneoplastic Neurologic Syndromes in Children: A Review Article

OBJECTIVE: Paraneoplastic neurological syndromes (PNS) were initially defined as neurological syndromes with unknown etiology that often associate with cancer. This broad definition may lead to misconception that any neurological syndrome, which coincides with a cancer might be considered as PNS. In...

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Autor principal: ALAVI, Samin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943073/
https://www.ncbi.nlm.nih.gov/pubmed/24665300
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author ALAVI, Samin
author_facet ALAVI, Samin
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description OBJECTIVE: Paraneoplastic neurological syndromes (PNS) were initially defined as neurological syndromes with unknown etiology that often associate with cancer. This broad definition may lead to misconception that any neurological syndrome, which coincides with a cancer might be considered as PNS. In the last two decades it has been suggested that PNSs are mainly immune-mediated. The detection of onconeural antibodies has been very helpful in indicating the existence of a tumor and defining a given neurological syndrome as paraneoplastic. However, PNS may occur without onconeural antibodies, and the antibodies can occur with no neurological syndrome; thus, their presence should not be the only condition to define a neurological syndrome as paraneoplastic. Diagnosis of paraneoplastic syndromes in children may result in early detection and treatment of the pediatric cancer and can reduce the neurological damage that is the major source of morbidity in children with successfully treated tumors. This study reviews the presenting symptoms, immunology, and management options for paraneoplastic syndromes, focusing on those most commonly reported in children.
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spelling pubmed-39430732014-03-24 Paraneoplastic Neurologic Syndromes in Children: A Review Article ALAVI, Samin Iran J Child Neurol Review Article OBJECTIVE: Paraneoplastic neurological syndromes (PNS) were initially defined as neurological syndromes with unknown etiology that often associate with cancer. This broad definition may lead to misconception that any neurological syndrome, which coincides with a cancer might be considered as PNS. In the last two decades it has been suggested that PNSs are mainly immune-mediated. The detection of onconeural antibodies has been very helpful in indicating the existence of a tumor and defining a given neurological syndrome as paraneoplastic. However, PNS may occur without onconeural antibodies, and the antibodies can occur with no neurological syndrome; thus, their presence should not be the only condition to define a neurological syndrome as paraneoplastic. Diagnosis of paraneoplastic syndromes in children may result in early detection and treatment of the pediatric cancer and can reduce the neurological damage that is the major source of morbidity in children with successfully treated tumors. This study reviews the presenting symptoms, immunology, and management options for paraneoplastic syndromes, focusing on those most commonly reported in children. Shahid Beheshti University of Medical Sciences 2013 /pmc/articles/PMC3943073/ /pubmed/24665300 Text en © 2013: Iranian Journal of Child Neurology This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
ALAVI, Samin
Paraneoplastic Neurologic Syndromes in Children: A Review Article
title Paraneoplastic Neurologic Syndromes in Children: A Review Article
title_full Paraneoplastic Neurologic Syndromes in Children: A Review Article
title_fullStr Paraneoplastic Neurologic Syndromes in Children: A Review Article
title_full_unstemmed Paraneoplastic Neurologic Syndromes in Children: A Review Article
title_short Paraneoplastic Neurologic Syndromes in Children: A Review Article
title_sort paraneoplastic neurologic syndromes in children: a review article
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943073/
https://www.ncbi.nlm.nih.gov/pubmed/24665300
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