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The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease

BACKGROUND: Sickle cell disease (SCD) often leads to chronic hemolytic anemia of varying severity, and blood transfusion may be employed in the management of SCD complications. OBJECTIVE: The aim of the study was to evaluate the effect of blood transfusion on the activities of some antioxidant enzym...

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Autores principales: Abiodun, Emokpae Mathias, Aisha, Kuliya-Gwarzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943147/
https://www.ncbi.nlm.nih.gov/pubmed/24678175
http://dx.doi.org/10.4103/0973-6247.126692
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author Abiodun, Emokpae Mathias
Aisha, Kuliya-Gwarzo
author_facet Abiodun, Emokpae Mathias
Aisha, Kuliya-Gwarzo
author_sort Abiodun, Emokpae Mathias
collection PubMed
description BACKGROUND: Sickle cell disease (SCD) often leads to chronic hemolytic anemia of varying severity, and blood transfusion may be employed in the management of SCD complications. OBJECTIVE: The aim of the study was to evaluate the effect of blood transfusion on the activities of some antioxidant enzymes as well as lipid peroxide and to relate transfusion status to these enzymes and malondialdehyde (MDA) in SCD patients. MATERIALS AND METHODS: Glutathione peroxidase (GPX), superoxide dismutase, catalase, MDA, and lipoproteins were assayed in 87 SCD and 20 age- and sex-matched subjects with normal hemoglobin. Of the 87 SCD patients, 30 had multiple transfusions, 21 had been transfused once while 36 had not been transfused within the last 3 months. RESULTS: Statistically significant decrease in the mean levels of GPX (P = 0.045) and Cu/Zn SOD (P = 0.001) and increased (P = 0.001) MDA were observed in the transfused compared to non-transfused patients. Similarly, significant decrease (P = 0.001) in Cu/Zn SOD and increase (P = 0.01) in MDA were observed in multi transfused compared to those who had been transfused once. Transfusion status correlated (P <0.047) inversely with Cu/Zn SOD and positively with MDA. CONCLUSION: Reduced activity levels of serum antioxidant enzymes and increased mean levels of MDA were observed in transfused compared to non-transfused SCD patients and these changes correlated with transfusion status.
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spelling pubmed-39431472014-03-27 The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease Abiodun, Emokpae Mathias Aisha, Kuliya-Gwarzo Asian J Transfus Sci Original Article BACKGROUND: Sickle cell disease (SCD) often leads to chronic hemolytic anemia of varying severity, and blood transfusion may be employed in the management of SCD complications. OBJECTIVE: The aim of the study was to evaluate the effect of blood transfusion on the activities of some antioxidant enzymes as well as lipid peroxide and to relate transfusion status to these enzymes and malondialdehyde (MDA) in SCD patients. MATERIALS AND METHODS: Glutathione peroxidase (GPX), superoxide dismutase, catalase, MDA, and lipoproteins were assayed in 87 SCD and 20 age- and sex-matched subjects with normal hemoglobin. Of the 87 SCD patients, 30 had multiple transfusions, 21 had been transfused once while 36 had not been transfused within the last 3 months. RESULTS: Statistically significant decrease in the mean levels of GPX (P = 0.045) and Cu/Zn SOD (P = 0.001) and increased (P = 0.001) MDA were observed in the transfused compared to non-transfused patients. Similarly, significant decrease (P = 0.001) in Cu/Zn SOD and increase (P = 0.01) in MDA were observed in multi transfused compared to those who had been transfused once. Transfusion status correlated (P <0.047) inversely with Cu/Zn SOD and positively with MDA. CONCLUSION: Reduced activity levels of serum antioxidant enzymes and increased mean levels of MDA were observed in transfused compared to non-transfused SCD patients and these changes correlated with transfusion status. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3943147/ /pubmed/24678175 http://dx.doi.org/10.4103/0973-6247.126692 Text en Copyright: © Asian Journal of Transfusion Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Abiodun, Emokpae Mathias
Aisha, Kuliya-Gwarzo
The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title_full The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title_fullStr The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title_full_unstemmed The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title_short The association of transfusion status with antioxidant enzymes and malondialdehyde level in Nigerians with sickle cell disease
title_sort association of transfusion status with antioxidant enzymes and malondialdehyde level in nigerians with sickle cell disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943147/
https://www.ncbi.nlm.nih.gov/pubmed/24678175
http://dx.doi.org/10.4103/0973-6247.126692
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