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Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples
In drug discovery and development, the quantification of drugs in biological samples is an important task for the determination of the physiological performance of the investigated drugs. After sampling, the next step in the analytical process is sample preparation. Because of the low concentration...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943203/ https://www.ncbi.nlm.nih.gov/pubmed/24688797 http://dx.doi.org/10.1155/2014/921350 |
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author | Moein, Mohammad Mahdi Said, Rana Bassyouni, Fatma Abdel-Rehim, Mohamed |
author_facet | Moein, Mohammad Mahdi Said, Rana Bassyouni, Fatma Abdel-Rehim, Mohamed |
author_sort | Moein, Mohammad Mahdi |
collection | PubMed |
description | In drug discovery and development, the quantification of drugs in biological samples is an important task for the determination of the physiological performance of the investigated drugs. After sampling, the next step in the analytical process is sample preparation. Because of the low concentration levels of drug in plasma and the variety of the metabolites, the selected extraction technique should be virtually exhaustive. Recent developments of sample handling techniques are directed, from one side, toward automatization and online coupling of sample preparation units. The primary objective of this review is to present the recent developments in microextraction sample preparation methods for analysis of drugs in biological fluids. Microextraction techniques allow for less consumption of solvent, reagents, and packing materials, and small sample volumes can be used. In this review the use of solid phase microextraction (SPME), microextraction in packed sorbent (MEPS), and stir-bar sorbtive extraction (SBSE) in drug analysis will be discussed. In addition, the use of new sorbents such as monoliths and molecularly imprinted polymers will be presented. |
format | Online Article Text |
id | pubmed-3943203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39432032014-03-31 Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples Moein, Mohammad Mahdi Said, Rana Bassyouni, Fatma Abdel-Rehim, Mohamed J Anal Methods Chem Review Article In drug discovery and development, the quantification of drugs in biological samples is an important task for the determination of the physiological performance of the investigated drugs. After sampling, the next step in the analytical process is sample preparation. Because of the low concentration levels of drug in plasma and the variety of the metabolites, the selected extraction technique should be virtually exhaustive. Recent developments of sample handling techniques are directed, from one side, toward automatization and online coupling of sample preparation units. The primary objective of this review is to present the recent developments in microextraction sample preparation methods for analysis of drugs in biological fluids. Microextraction techniques allow for less consumption of solvent, reagents, and packing materials, and small sample volumes can be used. In this review the use of solid phase microextraction (SPME), microextraction in packed sorbent (MEPS), and stir-bar sorbtive extraction (SBSE) in drug analysis will be discussed. In addition, the use of new sorbents such as monoliths and molecularly imprinted polymers will be presented. Hindawi Publishing Corporation 2014 2014-02-13 /pmc/articles/PMC3943203/ /pubmed/24688797 http://dx.doi.org/10.1155/2014/921350 Text en Copyright © 2014 Mohammad Mahdi Moein et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Moein, Mohammad Mahdi Said, Rana Bassyouni, Fatma Abdel-Rehim, Mohamed Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title | Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title_full | Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title_fullStr | Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title_full_unstemmed | Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title_short | Solid Phase Microextraction and Related Techniques for Drugs in Biological Samples |
title_sort | solid phase microextraction and related techniques for drugs in biological samples |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943203/ https://www.ncbi.nlm.nih.gov/pubmed/24688797 http://dx.doi.org/10.1155/2014/921350 |
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