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Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years

Testosterone deficiency leads to bone loss and testosterone treatment has a beneficial effect. This study investigated the effects of normalizing serum testosterone on bone mineral density in 45 men with osteoporosis, diagnosed with testosterone deficiency (serum testosterone levels <12.1 nmol/L,...

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Autores principales: Haider, Ahmad, Meergans, Ulrich, Traish, Abdulmaged, Saad, Farid, Doros, Gheorghe, Lips, Paul, Gooren, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943258/
https://www.ncbi.nlm.nih.gov/pubmed/24688541
http://dx.doi.org/10.1155/2014/496948
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author Haider, Ahmad
Meergans, Ulrich
Traish, Abdulmaged
Saad, Farid
Doros, Gheorghe
Lips, Paul
Gooren, Louis
author_facet Haider, Ahmad
Meergans, Ulrich
Traish, Abdulmaged
Saad, Farid
Doros, Gheorghe
Lips, Paul
Gooren, Louis
author_sort Haider, Ahmad
collection PubMed
description Testosterone deficiency leads to bone loss and testosterone treatment has a beneficial effect. This study investigated the effects of normalizing serum testosterone on bone mineral density in 45 men with osteoporosis, diagnosed with testosterone deficiency (serum testosterone levels <12.1 nmol/L, T-scores: (mean ± SD) −3.12 ± 0.45, minimum: −4.10, and maximum: −2.60). In a cumulative, prospective, registry study of hypogonadal men (mean age: 53 ± 7 years) they received parenteral testosterone undecanoate of 1000 mg/12 weeks for up to six years. After one year 44 men were included in the registry, after two years 36 men, after three years 32 men, after four years 25 men, after five years 10 men and after six years 4 men. The declining numbers do not reflect drop-out rates but are a result of the registry design. Over the 6 year period there was a significant and progressive improvement of the T-scores in these men. Normalizing of serum testosterone leads to an improvement of bone mineral density and this improvement was progressive with the time period of testosterone administration. In this study of 6-years many men with testosterone deficiency suffered from classical diagnoses (Klinefelter's syndrome and testicular pathology) hitherto undiagnosed.
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spelling pubmed-39432582014-03-31 Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years Haider, Ahmad Meergans, Ulrich Traish, Abdulmaged Saad, Farid Doros, Gheorghe Lips, Paul Gooren, Louis Int J Endocrinol Research Article Testosterone deficiency leads to bone loss and testosterone treatment has a beneficial effect. This study investigated the effects of normalizing serum testosterone on bone mineral density in 45 men with osteoporosis, diagnosed with testosterone deficiency (serum testosterone levels <12.1 nmol/L, T-scores: (mean ± SD) −3.12 ± 0.45, minimum: −4.10, and maximum: −2.60). In a cumulative, prospective, registry study of hypogonadal men (mean age: 53 ± 7 years) they received parenteral testosterone undecanoate of 1000 mg/12 weeks for up to six years. After one year 44 men were included in the registry, after two years 36 men, after three years 32 men, after four years 25 men, after five years 10 men and after six years 4 men. The declining numbers do not reflect drop-out rates but are a result of the registry design. Over the 6 year period there was a significant and progressive improvement of the T-scores in these men. Normalizing of serum testosterone leads to an improvement of bone mineral density and this improvement was progressive with the time period of testosterone administration. In this study of 6-years many men with testosterone deficiency suffered from classical diagnoses (Klinefelter's syndrome and testicular pathology) hitherto undiagnosed. Hindawi Publishing Corporation 2014 2014-02-13 /pmc/articles/PMC3943258/ /pubmed/24688541 http://dx.doi.org/10.1155/2014/496948 Text en Copyright © 2014 Ahmad Haider et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Haider, Ahmad
Meergans, Ulrich
Traish, Abdulmaged
Saad, Farid
Doros, Gheorghe
Lips, Paul
Gooren, Louis
Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title_full Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title_fullStr Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title_full_unstemmed Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title_short Progressive Improvement of T-Scores in Men with Osteoporosis and Subnormal Serum Testosterone Levels upon Treatment with Testosterone over Six Years
title_sort progressive improvement of t-scores in men with osteoporosis and subnormal serum testosterone levels upon treatment with testosterone over six years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943258/
https://www.ncbi.nlm.nih.gov/pubmed/24688541
http://dx.doi.org/10.1155/2014/496948
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