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Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment

Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little...

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Autores principales: Pezato, Rogério, de Almeida, Danilo Cândido, Bezerra, Thiago Freire, Silva, Fernando de Sá, Perez-Novo, Claudina, Gregório, Luís Carlos, Voegels, Richard Louis, Câmara, Niels Olsen, Bachert, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943259/
https://www.ncbi.nlm.nih.gov/pubmed/24707116
http://dx.doi.org/10.1155/2014/583409
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author Pezato, Rogério
de Almeida, Danilo Cândido
Bezerra, Thiago Freire
Silva, Fernando de Sá
Perez-Novo, Claudina
Gregório, Luís Carlos
Voegels, Richard Louis
Câmara, Niels Olsen
Bachert, Claus
author_facet Pezato, Rogério
de Almeida, Danilo Cândido
Bezerra, Thiago Freire
Silva, Fernando de Sá
Perez-Novo, Claudina
Gregório, Luís Carlos
Voegels, Richard Louis
Câmara, Niels Olsen
Bachert, Claus
author_sort Pezato, Rogério
collection PubMed
description Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition.
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spelling pubmed-39432592014-04-06 Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment Pezato, Rogério de Almeida, Danilo Cândido Bezerra, Thiago Freire Silva, Fernando de Sá Perez-Novo, Claudina Gregório, Luís Carlos Voegels, Richard Louis Câmara, Niels Olsen Bachert, Claus Mediators Inflamm Research Article Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity. Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored. Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu. After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease. Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response. We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition. Hindawi Publishing Corporation 2014 2014-02-13 /pmc/articles/PMC3943259/ /pubmed/24707116 http://dx.doi.org/10.1155/2014/583409 Text en Copyright © 2014 Rogério Pezato et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pezato, Rogério
de Almeida, Danilo Cândido
Bezerra, Thiago Freire
Silva, Fernando de Sá
Perez-Novo, Claudina
Gregório, Luís Carlos
Voegels, Richard Louis
Câmara, Niels Olsen
Bachert, Claus
Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title_full Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title_fullStr Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title_full_unstemmed Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title_short Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
title_sort immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943259/
https://www.ncbi.nlm.nih.gov/pubmed/24707116
http://dx.doi.org/10.1155/2014/583409
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