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Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer

BACKGROUND: Polyoxypeptin A was isolated from a culture broth of Streptomyces sp. MK498-98 F14, which has a potent apoptosis-inducing activity towards human pancreatic carcinoma AsPC-1 cells. Structurally, polyoxypeptin A is composed of a C(15) acyl side chain and a nineteen-membered cyclodepsipepti...

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Detalles Bibliográficos
Autores principales:	Du, Yanhua, Wang, Yemin, Huang, Tingting, Tao, Meifeng, Deng, Zixin, Lin, Shuangjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943440/ https://www.ncbi.nlm.nih.gov/pubmed/24506891 http://dx.doi.org/10.1186/1471-2180-14-30

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