A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

BACKGROUND: Mutations in either of two genes comprising the STSL locus, ATP-binding cassette (ABC)-transporters ABCG5 (encoding sterolin-1) and ABCG8 (encoding sterolin-2), result in sitosterolemia, a rare autosomal recessive disorder of sterol trafficking characterized by increased plasma plant ste...

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Detalles Bibliográficos
Autores principales: Klett, Eric L, Lu, Kangmo, Kosters, Astrid, Vink, Edwin, Lee, Mi-Hye, Altenburg, Michael, Shefer, Sarah, Batta, Ashok K, Yu, Hongwei, Chen, Jianliang, Klein, Richard, Looije, Norbert, Oude-Elferink, Ronald, Groen, Albert K, Maeda, Nobuyo, Salen, Gerald, Patel, Shailendra B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC394351/
https://www.ncbi.nlm.nih.gov/pubmed/15040800
http://dx.doi.org/10.1186/1741-7015-2-5

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