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Practical synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides via conventional and decarboxylative copper-free Sonogashira coupling reactions

Two efficient protocols for the palladium-catalyzed synthesis of aryl-2-methyl-3-butyn-2-ols from aryl bromides in the absence of copper were developed. A simple catalytic system consisting of Pd(OAc)(2) and P(p-tol)(3) using DBU as the base and THF as the solvent was found to be highly effective fo...

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Detalles Bibliográficos
Autores principales:	Caporale, Andrea, Tartaggia, Stefano, Castellin, Andrea, De Lucchi, Ottorino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2014
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943628/ https://www.ncbi.nlm.nih.gov/pubmed/24605159 http://dx.doi.org/10.3762/bjoc.10.36

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