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Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9

The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification of cells and organisms. Multiplex genetic engineering in rat holds a bright future for the study of complex disease. Here, we show that this system enables the simultaneous disruption of four genes (A...

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Detalles Bibliográficos
Autores principales:	Ma, Yuanwu, Shen, Bin, Zhang, Xu, Lu, Yingdong, Chen, Wei, Ma, Jing, Huang, Xingxu, Zhang, Lianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943732/ https://www.ncbi.nlm.nih.gov/pubmed/24598943 http://dx.doi.org/10.1371/journal.pone.0089413

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