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Preparation of new alkyne-modified ansamitocins by mutasynthesis

The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cycloaddition which can principally be utilized to...

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Detalles Bibliográficos
Autores principales:	Harmrolfs, Kirsten, Mancuso, Lena, Drung, Binia, Sasse, Florenz, Kirschning, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2014
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943755/ https://www.ncbi.nlm.nih.gov/pubmed/24605171 http://dx.doi.org/10.3762/bjoc.10.49

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