A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Polymyxin B and colistin were examined for their ability to inhibit the type II NADH-quinone oxidoreductases (NDH-2) of three species of Gram-negative bacteria. Polymyxin B and colistin inhibited the NDH-2 activity in preparations from all of the isolates in a concentration-dependent manner. The mec...

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Detalles Bibliográficos
Autores principales: Deris, Zakuan Z., Akter, Jesmin, Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Nation, Roger L., Li, Jian, Velkov, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943757/
https://www.ncbi.nlm.nih.gov/pubmed/24169795
http://dx.doi.org/10.1038/ja.2013.111

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