NFkB and Nrf2 in esophageal epithelial barrier function

The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Fang, Yu, Li, Wenbo, Orlando, Roy C, Shaheen, Nicholas, Chen, Xiaoxin Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943848/
https://www.ncbi.nlm.nih.gov/pubmed/24790804
http://dx.doi.org/10.4161/tisb.27463
Descripción
Sumario:The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD.

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