NFkB and Nrf2 in esophageal epithelial barrier function

The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Fang, Yu, Li, Wenbo, Orlando, Roy C, Shaheen, Nicholas, Chen, Xiaoxin Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943848/
https://www.ncbi.nlm.nih.gov/pubmed/24790804
http://dx.doi.org/10.4161/tisb.27463
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author Chen, Hao
Fang, Yu
Li, Wenbo
Orlando, Roy C
Shaheen, Nicholas
Chen, Xiaoxin Luke
author_facet Chen, Hao
Fang, Yu
Li, Wenbo
Orlando, Roy C
Shaheen, Nicholas
Chen, Xiaoxin Luke
author_sort Chen, Hao
collection PubMed
description The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD.
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spelling pubmed-39438482014-04-30 NFkB and Nrf2 in esophageal epithelial barrier function Chen, Hao Fang, Yu Li, Wenbo Orlando, Roy C Shaheen, Nicholas Chen, Xiaoxin Luke Tissue Barriers Commentary The stratified squamous epithelium of the esophagus forms a tight protective barrier. Defects of the barrier function contribute to gastroesophageal reflux disease (GERD), which is manifested as damage to the esophageal epithelium due to exposure to the gastrointestinal refluxate. In this review, we discuss the involvement of NFkB and Nrf2 in esophageal epithelial barrier function. Understanding these molecular pathways in the esophagus may help us develop therapeutic strategies to improve clinical outcomes in patients with GERD. Landes Bioscience 2013-12-01 2013-12-10 /pmc/articles/PMC3943848/ /pubmed/24790804 http://dx.doi.org/10.4161/tisb.27463 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Chen, Hao
Fang, Yu
Li, Wenbo
Orlando, Roy C
Shaheen, Nicholas
Chen, Xiaoxin Luke
NFkB and Nrf2 in esophageal epithelial barrier function
title NFkB and Nrf2 in esophageal epithelial barrier function
title_full NFkB and Nrf2 in esophageal epithelial barrier function
title_fullStr NFkB and Nrf2 in esophageal epithelial barrier function
title_full_unstemmed NFkB and Nrf2 in esophageal epithelial barrier function
title_short NFkB and Nrf2 in esophageal epithelial barrier function
title_sort nfkb and nrf2 in esophageal epithelial barrier function
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943848/
https://www.ncbi.nlm.nih.gov/pubmed/24790804
http://dx.doi.org/10.4161/tisb.27463
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AT shaheennicholas nfkbandnrf2inesophagealepithelialbarrierfunction
AT chenxiaoxinluke nfkbandnrf2inesophagealepithelialbarrierfunction

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