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Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction
Progenitor cells (PCs) contribute to the endogenous repair mechanism after ischemic events. Interleukin-8 (IL-8) as part of the acute inflammatory reaction may enhance PC mobilization. Also, statins are supposed to alter number and function of circulating PCs. We aimed to investigate PC mobilization...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943863/ https://www.ncbi.nlm.nih.gov/pubmed/24599235 http://dx.doi.org/10.1371/journal.pone.0070796 |
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author | Sepp, Dominik Franz, Daniela Triftshaeuser, Natalie Ott, Ilka Esposito-Bauer, Lorena Feurer, Regina Seifert, Christian L. Thaler, Markus Hemmer, Bernhard Poppert, Holger |
author_facet | Sepp, Dominik Franz, Daniela Triftshaeuser, Natalie Ott, Ilka Esposito-Bauer, Lorena Feurer, Regina Seifert, Christian L. Thaler, Markus Hemmer, Bernhard Poppert, Holger |
author_sort | Sepp, Dominik |
collection | PubMed |
description | Progenitor cells (PCs) contribute to the endogenous repair mechanism after ischemic events. Interleukin-8 (IL-8) as part of the acute inflammatory reaction may enhance PC mobilization. Also, statins are supposed to alter number and function of circulating PCs. We aimed to investigate PC mobilization after acute ischemic stroke as well as its association with inflammatory markers and statin therapy. Sixty-five patients with ischemic stroke were enrolled in the study. The number of CD133(+) PCs was analyzed by flow cytometry. Blood samples were drawn within 24 hours after symptom onset and after 5 days. The number of CD133(+) PCs increased significantly within 5 days (p<0.001). We found no correlation between CD133(+) PCs and the serum levels of IL-8, IL-6, or C-reactive protein (CRP). Multivariate analysis revealed that preexisting statin therapy correlated independently with the increase of CD133(+) PCs (p = 0.001). This study showed a mobilization of CD133(+) PCs in patients with acute cerebral infarction within 5 days after symptom onset. The early systemic inflammatory response did not seem to be a decisive factor in the mobilization of PCs. Preexisting statin therapy was associated with the increase in CD133(+) PCs, suggesting a potentially beneficial effect of statin therapy in patients with stroke. |
format | Online Article Text |
id | pubmed-3943863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39438632014-03-10 Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction Sepp, Dominik Franz, Daniela Triftshaeuser, Natalie Ott, Ilka Esposito-Bauer, Lorena Feurer, Regina Seifert, Christian L. Thaler, Markus Hemmer, Bernhard Poppert, Holger PLoS One Research Article Progenitor cells (PCs) contribute to the endogenous repair mechanism after ischemic events. Interleukin-8 (IL-8) as part of the acute inflammatory reaction may enhance PC mobilization. Also, statins are supposed to alter number and function of circulating PCs. We aimed to investigate PC mobilization after acute ischemic stroke as well as its association with inflammatory markers and statin therapy. Sixty-five patients with ischemic stroke were enrolled in the study. The number of CD133(+) PCs was analyzed by flow cytometry. Blood samples were drawn within 24 hours after symptom onset and after 5 days. The number of CD133(+) PCs increased significantly within 5 days (p<0.001). We found no correlation between CD133(+) PCs and the serum levels of IL-8, IL-6, or C-reactive protein (CRP). Multivariate analysis revealed that preexisting statin therapy correlated independently with the increase of CD133(+) PCs (p = 0.001). This study showed a mobilization of CD133(+) PCs in patients with acute cerebral infarction within 5 days after symptom onset. The early systemic inflammatory response did not seem to be a decisive factor in the mobilization of PCs. Preexisting statin therapy was associated with the increase in CD133(+) PCs, suggesting a potentially beneficial effect of statin therapy in patients with stroke. Public Library of Science 2014-03-05 /pmc/articles/PMC3943863/ /pubmed/24599235 http://dx.doi.org/10.1371/journal.pone.0070796 Text en © 2014 Sepp et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Sepp, Dominik Franz, Daniela Triftshaeuser, Natalie Ott, Ilka Esposito-Bauer, Lorena Feurer, Regina Seifert, Christian L. Thaler, Markus Hemmer, Bernhard Poppert, Holger Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title | Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title_full | Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title_fullStr | Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title_full_unstemmed | Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title_short | Mobilization of CD133(+) Progenitor Cells in Patients with Acute Cerebral Infarction |
title_sort | mobilization of cd133(+) progenitor cells in patients with acute cerebral infarction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943863/ https://www.ncbi.nlm.nih.gov/pubmed/24599235 http://dx.doi.org/10.1371/journal.pone.0070796 |
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