Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor peptide. Thiopeptides are especially active against Gram-positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). In this study the GE2270 biosynthet...

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Detalles Bibliográficos
Autores principales: Flinspach, Katrin, Kapitzke, Claudia, Tocchetti, Arianna, Sosio, Margherita, Apel, Alexander K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943966/
https://www.ncbi.nlm.nih.gov/pubmed/24598591
http://dx.doi.org/10.1371/journal.pone.0090499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943966/
https://www.ncbi.nlm.nih.gov/pubmed/24598591
http://dx.doi.org/10.1371/journal.pone.0090499

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