Cargando…

Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor peptide. Thiopeptides are especially active against Gram-positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). In this study the GE2270 biosynthet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flinspach, Katrin, Kapitzke, Claudia, Tocchetti, Arianna, Sosio, Margherita, Apel, Alexander K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943966/ https://www.ncbi.nlm.nih.gov/pubmed/24598591 http://dx.doi.org/10.1371/journal.pone.0090499

Ejemplares similares

Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A
por: Del Carratore, Francesco, et al.
Publicado: (2021)

A Genomic, Transcriptomic and Proteomic Look at the GE2270 Producer Planobispora rosea, an Uncommon Actinomycete
por: Tocchetti, Arianna, et al.
Publicado: (2015)

Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracellular medium
por: Giardina, Anna, et al.
Publicado: (2010)

Antibacterial Thiopeptide GE2270-Congeners from Nonomuraea jiangxiensis
por: Ching, Kuan-Chieh, et al.
Publicado: (2022)

Heterologous expression and purification of encapsulins in Streptomyces coelicolor
por: Andreas, Michael P., et al.
Publicado: (2022)

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters
por: Gomez‐Escribano, Juan Pablo, et al.
Publicado: (2011)

A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes
por: Thanapipatsiri, Anyarat, et al.
Publicado: (2015)

Analysis of gene expression in operons of Streptomyces coelicolor
por: Laing, Emma, et al.
Publicado: (2006)

Expression of genes of the Pho regulon is altered in Streptomyces coelicolor
por: Millan-Oropeza, Aaron, et al.
Publicado: (2020)

Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2)
por: Yin, Jia, et al.
Publicado: (2015)

Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
por: Sulheim, Snorre, et al.
Publicado: (2020)

Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor
por: Li, Hong, et al.
Publicado: (2021)

Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor
por: Gu, Boncheol, et al.
Publicado: (2023)

OBSERVATIONS ON THE CHROMATINIC BODIES OF Streptomyces coelicolor
por: Hopwood, David A., et al.
Publicado: (1960)

Proteomic survey of the Streptomyces coelicolor nucleoid
por: Bradshaw, Elizabeth, et al.
Publicado: (2013)

Therapies from Thiopeptides
por: Hwang, Hee-Jong, et al.
Publicado: (2023)

Multicopy Chromosome Integration and Deletion of Negative Global Regulators Significantly Increased the Heterologous Production of Aborycin in Streptomyces coelicolor
por: Li, Jia-Yi, et al.
Publicado: (2023)

A Membranous Component of the Cytoplasm in Streptomyces coelicolor
por: Glauert, Audrey M., et al.
Publicado: (1959)

Small non-coding RNAs in Streptomyces coelicolor
por: Swiercz, Julia P., et al.
Publicado: (2008)

The dynamic architecture of the metabolic switch in Streptomyces coelicolor
por: Nieselt, Kay, et al.
Publicado: (2010)

Streptomyces coelicolor Vesicles: Many Molecules To Be Delivered
por: Faddetta, Teresa, et al.
Publicado: (2022)

Prodiginines Postpone the Onset of Sporulation in Streptomyces coelicolor
por: Tenconi, Elodie, et al.
Publicado: (2020)

Streptomyces as Microbial Chassis for Heterologous Protein Expression
por: Hwang, Soonkyu, et al.
Publicado: (2021)

Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic
por: Schneider, Olha, et al.
Publicado: (2018)

De novo biosynthesis of myricetin, kaempferol and quercetin in Streptomyces albus and Streptomyces coelicolor
por: Marín, Laura, et al.
Publicado: (2018)

THE FINE STRUCTURE OF Streptomyces coelicolor : II. The Nuclear Material
por: Hopwood, David A., et al.
Publicado: (1960)

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor
por: Alam, Mohammad T, et al.
Publicado: (2010)

Robust, small-scale cultivation platform for Streptomyces coelicolor
por: Sohoni, Sujata Vijay, et al.
Publicado: (2012)

ArgR of Streptomyces coelicolor Is a Versatile Regulator
por: Pérez-Redondo, Rosario, et al.
Publicado: (2012)

Genome-wide inference of regulatory networks in Streptomyces coelicolor
por: Castro-Melchor, Marlene, et al.
Publicado: (2010)

Secondary Metabolites Produced during the Germination of Streptomyces coelicolor
por: Čihák, Matouš, et al.
Publicado: (2017)

Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor
por: Alam, Mohammad Tauqeer, et al.
Publicado: (2011)

Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor
por: Willemse, Joost, et al.
Publicado: (2011)

Green fluorescent protein as a reporter for the spatial and temporal expression of actIII in Streptomyces coelicolor
por: Santos-Beneit, Fernando, et al.
Publicado: (2017)

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor
por: Sola-Landa, Alberto, et al.
Publicado: (2008)

Thiopeptide Antibiotics: Retrospective and Recent Advances
por: Just-Baringo, Xavier, et al.
Publicado: (2014)

Draft Genome Sequence of Streptomyces sp. M1013, a Close Relative of Streptomyces ambofaciens and Streptomyces coelicolor
por: Haas, Drago, et al.
Publicado: (2017)

Deletion of MtrA Inhibits Cellular Development of Streptomyces coelicolor and Alters Expression of Developmental Regulatory Genes
por: Zhang, Peipei, et al.
Publicado: (2017)

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor
por: Haiser, Henry J., et al.
Publicado: (2008)

Transcriptome dynamics-based operon prediction and verification in Streptomyces coelicolor
por: Charaniya, Salim, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_vsvk3q6f7mcp8mrc3oam6ftqrt