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Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C

Single nucleotide polymorphisms of interleukin-28B (IL28B) rs8099917 are reported to be associated with virologic clearance in interferon-and ribavirin -based treatment for hepatitis C virus (HCV)-infected patients. We examined virologic response in accordance with IL28B polymorphisms in our living...

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Autores principales: Harada, Nobuhiro, Tamura, Sumihito, Sugawara, Yasuhiko, Togashi, Junichi, Ishizawa, Takeaki, Kaneko, Junichi, Aoki, Taku, Sakamoto, Yoshihiro, Hasegawa, Kiyoshi, Tanaka, Tomohiro, Yamashiki, Noriyo, Kokudo, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944011/
https://www.ncbi.nlm.nih.gov/pubmed/24599320
http://dx.doi.org/10.1371/journal.pone.0090462
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author Harada, Nobuhiro
Tamura, Sumihito
Sugawara, Yasuhiko
Togashi, Junichi
Ishizawa, Takeaki
Kaneko, Junichi
Aoki, Taku
Sakamoto, Yoshihiro
Hasegawa, Kiyoshi
Tanaka, Tomohiro
Yamashiki, Noriyo
Kokudo, Norihiro
author_facet Harada, Nobuhiro
Tamura, Sumihito
Sugawara, Yasuhiko
Togashi, Junichi
Ishizawa, Takeaki
Kaneko, Junichi
Aoki, Taku
Sakamoto, Yoshihiro
Hasegawa, Kiyoshi
Tanaka, Tomohiro
Yamashiki, Noriyo
Kokudo, Norihiro
author_sort Harada, Nobuhiro
collection PubMed
description Single nucleotide polymorphisms of interleukin-28B (IL28B) rs8099917 are reported to be associated with virologic clearance in interferon-and ribavirin -based treatment for hepatitis C virus (HCV)-infected patients. We examined virologic response in accordance with IL28B polymorphisms in our living donor liver transplantation series under a preemptive interferon and RBV treatment approach. Adequate DNA samples from both the recipient and donor for the study of single nucleotide polymorphisms of IL28B were available from 96 cases and were the subjects of the present study. Various clinical factors related with virologic response including early virologic response (EVR) and sustained virologic response (SVR) were examined. Totally 51% presented with EVR and 44% achieved SVR. Presence of the major allele (TT) in either the recipient or the donor corresponded to SVR of 53% and 48%. Presence of the minor allele (TG or GG) corresponded to SVR of 26% and 32%. Multivariate analysis revealed that genotype of HCV or EVR, but not IL28B polymorphisms in either the recipient or donor, was an independent factor for achieving SVR. When virologic response to treatment was incorporated into analysis, the impact of IL28B polymorphism on virological clearance remained relative to other factors and was not significantly independent.
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spelling pubmed-39440112014-03-10 Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C Harada, Nobuhiro Tamura, Sumihito Sugawara, Yasuhiko Togashi, Junichi Ishizawa, Takeaki Kaneko, Junichi Aoki, Taku Sakamoto, Yoshihiro Hasegawa, Kiyoshi Tanaka, Tomohiro Yamashiki, Noriyo Kokudo, Norihiro PLoS One Research Article Single nucleotide polymorphisms of interleukin-28B (IL28B) rs8099917 are reported to be associated with virologic clearance in interferon-and ribavirin -based treatment for hepatitis C virus (HCV)-infected patients. We examined virologic response in accordance with IL28B polymorphisms in our living donor liver transplantation series under a preemptive interferon and RBV treatment approach. Adequate DNA samples from both the recipient and donor for the study of single nucleotide polymorphisms of IL28B were available from 96 cases and were the subjects of the present study. Various clinical factors related with virologic response including early virologic response (EVR) and sustained virologic response (SVR) were examined. Totally 51% presented with EVR and 44% achieved SVR. Presence of the major allele (TT) in either the recipient or the donor corresponded to SVR of 53% and 48%. Presence of the minor allele (TG or GG) corresponded to SVR of 26% and 32%. Multivariate analysis revealed that genotype of HCV or EVR, but not IL28B polymorphisms in either the recipient or donor, was an independent factor for achieving SVR. When virologic response to treatment was incorporated into analysis, the impact of IL28B polymorphism on virological clearance remained relative to other factors and was not significantly independent. Public Library of Science 2014-03-05 /pmc/articles/PMC3944011/ /pubmed/24599320 http://dx.doi.org/10.1371/journal.pone.0090462 Text en © 2014 Harada et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Harada, Nobuhiro
Tamura, Sumihito
Sugawara, Yasuhiko
Togashi, Junichi
Ishizawa, Takeaki
Kaneko, Junichi
Aoki, Taku
Sakamoto, Yoshihiro
Hasegawa, Kiyoshi
Tanaka, Tomohiro
Yamashiki, Noriyo
Kokudo, Norihiro
Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title_full Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title_fullStr Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title_full_unstemmed Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title_short Impact of Donor and Recipient Single Nucleotide Polymorphisms of IL28B rs8099917 in Living Donor Liver Transplantation for Hepatitis C
title_sort impact of donor and recipient single nucleotide polymorphisms of il28b rs8099917 in living donor liver transplantation for hepatitis c
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944011/
https://www.ncbi.nlm.nih.gov/pubmed/24599320
http://dx.doi.org/10.1371/journal.pone.0090462
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