Cargando…

Virtualizing the p-ANAPL Library: A Step towards Drug Discovery from African Medicinal Plants

BACKGROUND: Natural products play a key role in drug discovery programs, both serving as drugs and as templates for the synthesis of drugs, even though the quantities and availabilities of samples for screening are often limitted. EXPERIMENTAL APPROACH: A current collection of physical samples of &g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ntie-Kang, Fidele, Amoa Onguéné, Pascal, Fotso, Ghislain W., Andrae-Marobela, Kerstin, Bezabih, Merhatibeb, Ndom, Jean Claude, Ngadjui, Bonaventure T., Ogundaini, Abiodun O., Abegaz, Berhanu M., Meva’a, Luc Mbaze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944075/ https://www.ncbi.nlm.nih.gov/pubmed/24599120 http://dx.doi.org/10.1371/journal.pone.0090655

Ejemplares similares

Screening of the Pan-African Natural Product Library Identifies Ixoratannin A-2 and Boldine as Novel HIV-1 Inhibitors
por: Tietjen, Ian, et al.
Publicado: (2015)

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
por: Ntie-Kang, Fidele, et al.
Publicado: (2014)

The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids
por: Amoa Onguéné, Pascal, et al.
Publicado: (2013)

The potential of anti-malarial compounds derived from African medicinal plants, part III: an in silico evaluation of drug metabolism and pharmacokinetics profiling
por: Onguéné, Pascal Amoa, et al.
Publicado: (2014)

CamMedNP: Building the Cameroonian 3D structural natural products database for virtual screening
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells
por: Kuete, Victor, et al.
Publicado: (2018)

AfroDb: A Select Highly Potent and Diverse Natural Product Library from African Medicinal Plants
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants
por: Ntie-Kang, Fidele, et al.
Publicado: (2016)

Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone
por: Ngnintedo, Dominique, et al.
Publicado: (2016)

Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus
por: Duncan, Maggie C., et al.
Publicado: (2020)

Cameroonian medicinal plants: a bioactivity versus ethnobotanical survey and chemotaxonomic classification
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Assessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approach
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae)
por: Kuete, Victor, et al.
Publicado: (2011)

In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing
por: Karaman, Berin, et al.
Publicado: (2018)

The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019
por: Bekono, Boris D., et al.
Publicado: (2020)

Anthelmintic Activity and Cytotoxic Effects of Compounds Isolated from the Fruits of Ozoroa insignis Del. (Anacardiaceae)
por: Dube, Mthandazo, et al.
Publicado: (2021)

Synthesis of Novel Stilbene–Coumarin Derivatives and Antifungal Screening of Monotes kerstingii-Specialized Metabolites Against Fusarium oxysporum
por: Fotso, Ghislain Wabo, et al.
Publicado: (2020)

Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from Acacia polyacantha Willd. against MDR Gram-Negative Bacteria
por: Mambe, Flora T., et al.
Publicado: (2019)

Bilateral polyotia: case of a rare and atypical congenital malformation in a three-month-old infant
por: Biouélé, Roger Christian Meva’a, et al.
Publicado: (2021)

Chemical Constituents of Macaranga occidentalis, Antimicrobial and Chemophenetic Studies
por: Kamso, Viviane Flore Kamlo, et al.
Publicado: (2022)

An in silico evaluation of the ADMET profile of the StreptomeDB database
por: Ntie-Kang, Fidele
Publicado: (2013)

Predictive analysis of the value of information flow on the shop floor of developing countries using artificial neural network based deep learning
por: Mbakop, André Marie, et al.
Publicado: (2021)

Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines
por: Youmbi, Laetitia M., et al.
Publicado: (2023)

Editorial to Special Issue—“Structure-Activity Relationships (SAR) of Natural Products”
por: Sippl, Wolfgang, et al.
Publicado: (2021)

Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Araliopsis soyauxii Engl. (Rutaceae)
por: Noulala, Cédric Guy Tchatchouang, et al.
Publicado: (2022)

Is Women’s Engagement in Women’s Development Groups Associated with Enhanced Utilization of Maternal and Neonatal Health Services? A Cross-Sectional Study in Ethiopia
por: Gebregizabher, Fisseha Ashebir, et al.
Publicado: (2023)

Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
por: Seukep, Jackson A., et al.
Publicado: (2015)

A coupled thermo-mechanical damage model for fired clay bricks based on the unified strength theory
por: Mpoung, Léon Arnaud, et al.
Publicado: (2021)

Medicinal Plant Preparations Administered by Botswana Traditional Health Practitioners for Treatment of Worm Infections Show Anthelmintic Activities
por: Dube, Mthandazo, et al.
Publicado: (2022)

Natural Products as Modulators of Sirtuins
por: Karaman Mayack, Berin, et al.
Publicado: (2020)

Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes
por: Seukep, Jackson A., et al.
Publicado: (2016)

Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2
por: Ebob, Oyere Tanyi, et al.
Publicado: (2021)

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
por: Sharma, Pooja, et al.
Publicado: (2021)

Protease-inhibiting, molecular modeling and antimicrobial activities of extracts and constituents from Helichrysum foetidum and Helichrysum mechowianum (compositae)
por: Malolo, Fanny-Aimée Essombe, et al.
Publicado: (2015)

Data on the estimation of thermomechanical damage for fired clay bricks
por: Mpoung, Léon Arnaud, et al.
Publicado: (2021)

ISOLATION AND CHARACTERIZATION OF CHEMICAL CONSTITUENTS FROM CHRYSOPHYLLUM ALBIDUM G. DON-HOLL. STEM-BARK EXTRACTS AND THEIR ANTIOXIDANT AND ANTIBACTERIAL PROPERTIES
por: Idowu, T.O., et al.
Publicado: (2016)

Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii (Rutaceae)
por: Sandjo, Louis P, et al.
Publicado: (2014)

Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes
por: Djeussi, Doriane E., et al.
Publicado: (2016)

Editorial: Natural Product Epigenetic Modulators and Inhibitors
por: Ntie-Kang, Fidele, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_onhvrees5csihsnrdho01qmgrq