Effect of CYP3A4*22, CYP3A5*3, and CYP3A Combined Genotypes on Cyclosporine, Everolimus, and Tacrolimus Pharmacokinetics in Renal Transplantation

Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive therapy in renal transplantation. These drugs are characterized by narrow therapeutic windows, highly variable pharmacokinetics (PK), and metabolism by CYP3A enzymes. Recently, the decreased activity allele, CYP3A4*22,...

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Detalles Bibliográficos
Autores principales: Moes, D J A R, Swen, J J, den Hartigh, J, van der Straaten, T, van der Heide, J J Homan, Sanders, J S, Bemelman, F J, de Fijter, J W, Guchelaar, H J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944116/
https://www.ncbi.nlm.nih.gov/pubmed/24522145
http://dx.doi.org/10.1038/psp.2013.78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944116/
https://www.ncbi.nlm.nih.gov/pubmed/24522145
http://dx.doi.org/10.1038/psp.2013.78

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