Suppression of tumor angiogenesis by targeting the protein neddylation pathway

Inhibition of protein neddylation, particularly cullin neddylation, has emerged as a promising anticancer strategy, as evidenced by the antitumor activity in preclinical studies of the Nedd8-activating enzyme (NAE) inhibitor MLN4924. This small molecule can block the protein neddylation pathway and...

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Detalles Bibliográficos
Autores principales: Yao, W-T, Wu, J-F, Yu, G-Y, Wang, R, Wang, K, Li, L-H, Chen, P, Jiang, Y-N, Cheng, H, Lee, H W, Yu, J, Qi, H, Yu, X-J, Wang, P, Chu, Y-W, Yang, M, Hua, Z-C, Ying, H-Q, Hoffman, R M, Jeong, L S, Jia, L-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944239/
https://www.ncbi.nlm.nih.gov/pubmed/24525735
http://dx.doi.org/10.1038/cddis.2014.21

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