S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability

Here, we show for the first time that the familial breast/ovarian cancer susceptibility gene, BRCA1, along with interacting ΔNp63 proteins, transcriptionally upregulate the putative tumour suppressor protein, S100A2. Both BRCA1 and ΔNp63 proteins are required for S100A2 expression. BRCA1 requires ΔN...

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Detalles Bibliográficos
Autores principales: Buckley, N E, D'Costa, Z, Kaminska, M, Mullan, P B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944248/
https://www.ncbi.nlm.nih.gov/pubmed/24556685
http://dx.doi.org/10.1038/cddis.2014.31

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944248/
https://www.ncbi.nlm.nih.gov/pubmed/24556685
http://dx.doi.org/10.1038/cddis.2014.31

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