Cargando…

Metabolism addiction in pancreatic cancer

Pancreatic ductal adenocarcinoma, an aggressively invasive, treatment-resistant malignancy and the fourth leading cause of cancer deaths in the United States, is usually detectable only when already inevitably fatal. Despite advances in genetic screening, mapping and molecular characterization, its...

Descripción completa

Detalles Bibliográficos
Autores principales: Blum, R, Kloog, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944253/
https://www.ncbi.nlm.nih.gov/pubmed/24556680
http://dx.doi.org/10.1038/cddis.2014.38
_version_ 1782306351259582464
author Blum, R
Kloog, Y
author_facet Blum, R
Kloog, Y
author_sort Blum, R
collection PubMed
description Pancreatic ductal adenocarcinoma, an aggressively invasive, treatment-resistant malignancy and the fourth leading cause of cancer deaths in the United States, is usually detectable only when already inevitably fatal. Despite advances in genetic screening, mapping and molecular characterization, its pathology remains largely elusive. Renewed research interest in longstanding doctrines of tumor metabolism has led to the emergence of aberrant signaling pathways as critical factors modulating central metabolic networks that fuel pancreatic tumors. Such pathways, including those of Ras signaling, glutamine-regulatory enzymes, lipid metabolism and autophagy, are directly affected by genetic mutations and extreme tumor microenvironments that typify pancreatic tumor cells. Elucidation of these metabolic networks can be expected to yield more potent therapies against this deadly disease.
format Online
Article
Text
id pubmed-3944253
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-39442532014-03-06 Metabolism addiction in pancreatic cancer Blum, R Kloog, Y Cell Death Dis Review Pancreatic ductal adenocarcinoma, an aggressively invasive, treatment-resistant malignancy and the fourth leading cause of cancer deaths in the United States, is usually detectable only when already inevitably fatal. Despite advances in genetic screening, mapping and molecular characterization, its pathology remains largely elusive. Renewed research interest in longstanding doctrines of tumor metabolism has led to the emergence of aberrant signaling pathways as critical factors modulating central metabolic networks that fuel pancreatic tumors. Such pathways, including those of Ras signaling, glutamine-regulatory enzymes, lipid metabolism and autophagy, are directly affected by genetic mutations and extreme tumor microenvironments that typify pancreatic tumor cells. Elucidation of these metabolic networks can be expected to yield more potent therapies against this deadly disease. Nature Publishing Group 2014-02 2014-02-20 /pmc/articles/PMC3944253/ /pubmed/24556680 http://dx.doi.org/10.1038/cddis.2014.38 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Blum, R
Kloog, Y
Metabolism addiction in pancreatic cancer
title Metabolism addiction in pancreatic cancer
title_full Metabolism addiction in pancreatic cancer
title_fullStr Metabolism addiction in pancreatic cancer
title_full_unstemmed Metabolism addiction in pancreatic cancer
title_short Metabolism addiction in pancreatic cancer
title_sort metabolism addiction in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944253/
https://www.ncbi.nlm.nih.gov/pubmed/24556680
http://dx.doi.org/10.1038/cddis.2014.38
work_keys_str_mv AT blumr metabolismaddictioninpancreaticcancer
AT kloogy metabolismaddictioninpancreaticcancer