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TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

New evidence indicates the involvement of protein degradation dysfunctions in neurodegeneration, innate immunity response and alcohol hepatotoxicity. We recently demonstrated that ethanol increases brain proinflammatory mediators and causes brain damage by activating Toll-like receptor 4 (TLR4) sign...

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Detalles Bibliográficos
Autores principales:	Pla, A, Pascual, M, Renau-Piqueras, J, Guerri, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944260/ https://www.ncbi.nlm.nih.gov/pubmed/24556681 http://dx.doi.org/10.1038/cddis.2014.46

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