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Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation

Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading to growing performance variability (i.e., state instability) in an individual and among subjects. Task duration plays a major role in the maint...

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Autores principales: Maire, Micheline, Reichert, Carolin F., Gabel, Virginie, Viola, Antoine U., Krebs, Julia, Strobel, Werner, Landolt, Hans-Peter, Bachmann, Valérie, Cajochen, Christian, Schmidt, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944366/
https://www.ncbi.nlm.nih.gov/pubmed/24639634
http://dx.doi.org/10.3389/fnbeh.2014.00059
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author Maire, Micheline
Reichert, Carolin F.
Gabel, Virginie
Viola, Antoine U.
Krebs, Julia
Strobel, Werner
Landolt, Hans-Peter
Bachmann, Valérie
Cajochen, Christian
Schmidt, Christina
author_facet Maire, Micheline
Reichert, Carolin F.
Gabel, Virginie
Viola, Antoine U.
Krebs, Julia
Strobel, Werner
Landolt, Hans-Peter
Bachmann, Valérie
Cajochen, Christian
Schmidt, Christina
author_sort Maire, Micheline
collection PubMed
description Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading to growing performance variability (i.e., state instability) in an individual and among subjects. Task duration plays a major role in the maintenance of stable vigilance levels, such that the longer the task, the more likely state instability will be observed. Vulnerability to sleep-loss-dependent performance decrements is highly individual and is also modulated by a polymorphism in the human clock gene PERIOD3 (PER3). By combining two different protocols, we manipulated sleep-wake history by once extending wakefulness for 40 h (high sleep pressure condition) and once by imposing a short sleep-wake cycle by alternating 160 min of wakefulness and 80 min naps (low sleep pressure condition) in a within-subject design. We observed that homozygous carriers of the long repeat allele of PER3 (PER3(5/5)) experienced a greater time-on-task dependent performance decrement (i.e., a steeper increase in the number of lapses) in the Psychomotor Vigilance Task compared to the carriers of the short repeat allele (PER3(4/4)). These genotype-dependent effects disappeared under low sleep pressure conditions, and neither motivation, nor perceived effort accounted for these differences. Our data thus suggest that greater sleep-loss related attentional vulnerability based on the PER3 polymorphism is mirrored by a greater state instability under extended wakefulness in the short compared to the long allele carriers. Our results undermine the importance of time-on-task related aspects when investigating inter-individual differences in sleep loss-induced behavioral vulnerability.
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spelling pubmed-39443662014-03-17 Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation Maire, Micheline Reichert, Carolin F. Gabel, Virginie Viola, Antoine U. Krebs, Julia Strobel, Werner Landolt, Hans-Peter Bachmann, Valérie Cajochen, Christian Schmidt, Christina Front Behav Neurosci Neuroscience Under sleep loss, vigilance is reduced and attentional failures emerge progressively. It becomes difficult to maintain stable performance over time, leading to growing performance variability (i.e., state instability) in an individual and among subjects. Task duration plays a major role in the maintenance of stable vigilance levels, such that the longer the task, the more likely state instability will be observed. Vulnerability to sleep-loss-dependent performance decrements is highly individual and is also modulated by a polymorphism in the human clock gene PERIOD3 (PER3). By combining two different protocols, we manipulated sleep-wake history by once extending wakefulness for 40 h (high sleep pressure condition) and once by imposing a short sleep-wake cycle by alternating 160 min of wakefulness and 80 min naps (low sleep pressure condition) in a within-subject design. We observed that homozygous carriers of the long repeat allele of PER3 (PER3(5/5)) experienced a greater time-on-task dependent performance decrement (i.e., a steeper increase in the number of lapses) in the Psychomotor Vigilance Task compared to the carriers of the short repeat allele (PER3(4/4)). These genotype-dependent effects disappeared under low sleep pressure conditions, and neither motivation, nor perceived effort accounted for these differences. Our data thus suggest that greater sleep-loss related attentional vulnerability based on the PER3 polymorphism is mirrored by a greater state instability under extended wakefulness in the short compared to the long allele carriers. Our results undermine the importance of time-on-task related aspects when investigating inter-individual differences in sleep loss-induced behavioral vulnerability. Frontiers Media S.A. 2014-03-06 /pmc/articles/PMC3944366/ /pubmed/24639634 http://dx.doi.org/10.3389/fnbeh.2014.00059 Text en Copyright © 2014 Maire, Reichert, Gabel, Viola, Krebs, Strobel, Landolt, Bachmann, Cajochen and Schmidt. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Maire, Micheline
Reichert, Carolin F.
Gabel, Virginie
Viola, Antoine U.
Krebs, Julia
Strobel, Werner
Landolt, Hans-Peter
Bachmann, Valérie
Cajochen, Christian
Schmidt, Christina
Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title_full Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title_fullStr Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title_full_unstemmed Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title_short Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
title_sort time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944366/
https://www.ncbi.nlm.nih.gov/pubmed/24639634
http://dx.doi.org/10.3389/fnbeh.2014.00059
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