Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells

14-3-3ζ is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3ζ decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like ce...

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Detalles Bibliográficos
Autores principales: Lee, Young Ki, Hur, Wonhee, Lee, Sung Won, Hong, Sung Woo, Kim, Sung Woo, Choi, Jung Eun, Yoon, Seung Kew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944442/
https://www.ncbi.nlm.nih.gov/pubmed/24556826
http://dx.doi.org/10.1038/emm.2013.151
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author Lee, Young Ki
Hur, Wonhee
Lee, Sung Won
Hong, Sung Woo
Kim, Sung Woo
Choi, Jung Eun
Yoon, Seung Kew
author_facet Lee, Young Ki
Hur, Wonhee
Lee, Sung Won
Hong, Sung Woo
Kim, Sung Woo
Choi, Jung Eun
Yoon, Seung Kew
author_sort Lee, Young Ki
collection PubMed
description 14-3-3ζ is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3ζ decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3ζ decreased cell viability and the number of spheres by reducing radioresistance in CSCs after γ-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3ζ after IR. These results suggest that 14-3-3ζ knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.
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spelling pubmed-39444422014-03-06 Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells Lee, Young Ki Hur, Wonhee Lee, Sung Won Hong, Sung Woo Kim, Sung Woo Choi, Jung Eun Yoon, Seung Kew Exp Mol Med Original Article 14-3-3ζ is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3ζ decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3ζ decreased cell viability and the number of spheres by reducing radioresistance in CSCs after γ-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3ζ after IR. These results suggest that 14-3-3ζ knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs. Nature Publishing Group 2014-02 2014-02-21 /pmc/articles/PMC3944442/ /pubmed/24556826 http://dx.doi.org/10.1038/emm.2013.151 Text en Copyright © 2014 KSBMB. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Lee, Young Ki
Hur, Wonhee
Lee, Sung Won
Hong, Sung Woo
Kim, Sung Woo
Choi, Jung Eun
Yoon, Seung Kew
Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title_full Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title_fullStr Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title_full_unstemmed Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title_short Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells
title_sort knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in cd133(+) liver cancer stem cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944442/
https://www.ncbi.nlm.nih.gov/pubmed/24556826
http://dx.doi.org/10.1038/emm.2013.151
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