The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction. In human clinical trials and rat models of inflammatory pain, peripherally restricted opioids have...

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Detalles Bibliográficos
Autores principales: Nockemann, Dinah, Rouault, Morgane, Labuz, Dominika, Hublitz, Philip, McKnelly, Kate, Reis, Fernanda C, Stein, Christoph, Heppenstall, Paul A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944465/
https://www.ncbi.nlm.nih.gov/pubmed/23818182
http://dx.doi.org/10.1002/emmm.201201980

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