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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

X-linked Inhibitor of Apoptosis (XIAP) is an essential ubiquitin ligase for pro-inflammatory signalling downstream of the nucleotide-binding oligomerization domain containing (NOD)-1 and -2 pattern recognition receptors. Mutations in XIAP cause X-linked lymphoproliferative syndrome type-2 (XLP2), an...

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Detalles Bibliográficos
Autores principales:	Damgaard, Rune Busk, Fiil, Berthe Katrine, Speckmann, Carsten, Yabal, Monica, zur Stadt, Udo, Bekker-Jensen, Simon, Jost, Philipp J, Ehl, Stephan, Mailand, Niels, Gyrd-Hansen, Mads
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Science Inc 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944466/ https://www.ncbi.nlm.nih.gov/pubmed/23818254 http://dx.doi.org/10.1002/emmm.201303090

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