Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells

Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. To gain insight into the physiological function of NCU-G1, mice with no det...

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Detalles Bibliográficos
Autores principales: Kong, Xiang Y., Nesset, Cecilie Kasi, Damme, Markus, Løberg, Else-Marit, Lübke, Torben, Mæhlen, Jan, Andersson, Kristin B., Lorenzo, Petra I., Roos, Norbert, Thoresen, G. Hege, Rustan, Arild C., Kase, Eili T., Eskild, Winnie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944495/
https://www.ncbi.nlm.nih.gov/pubmed/24487409
http://dx.doi.org/10.1242/dmm.014050

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