Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea

Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The abs...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Wei, Li, Jiao, E, Heng-Chao, Liu, Bao-Shu, Tang, Hua, Gerwick, William H., Hua, Hui-Ming, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944505/
https://www.ncbi.nlm.nih.gov/pubmed/24473165
http://dx.doi.org/10.3390/md12020589
Descripción
Sumario:Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.

Ejemplares similares