Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea

Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The abs...

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Autores principales: Zhou, Wei, Li, Jiao, E, Heng-Chao, Liu, Bao-Shu, Tang, Hua, Gerwick, William H., Hua, Hui-Ming, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944505/
https://www.ncbi.nlm.nih.gov/pubmed/24473165
http://dx.doi.org/10.3390/md12020589
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author Zhou, Wei
Li, Jiao
E, Heng-Chao
Liu, Bao-Shu
Tang, Hua
Gerwick, William H.
Hua, Hui-Ming
Zhang, Wen
author_facet Zhou, Wei
Li, Jiao
E, Heng-Chao
Liu, Bao-Shu
Tang, Hua
Gerwick, William H.
Hua, Hui-Ming
Zhang, Wen
author_sort Zhou, Wei
collection PubMed
description Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay.
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spelling pubmed-39445052014-03-07 Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea Zhou, Wei Li, Jiao E, Heng-Chao Liu, Bao-Shu Tang, Hua Gerwick, William H. Hua, Hui-Ming Zhang, Wen Mar Drugs Four new briarane diterpenoids, junceellolides M–P (1–4), were isolated together with seven known analogs (5–11) from the South China Sea gorgonian, Junceella gemmacea. The structures of these compounds were elucidated by detailed spectroscopic analysis and comparison with the reported data. The absolute configuration of compounds 1–3 were determined based on an ECD experiment, while the absolute configuration of compound 4 was genetically determined. All the compounds were isolated for the first time from J. gemmacea. These compounds showed no growth inhibitory activity against A549, MG63 and SMMC-7721 cell lines in an in vitro bioassay. MDPI 2014-01-27 /pmc/articles/PMC3944505/ /pubmed/24473165 http://dx.doi.org/10.3390/md12020589 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Zhou, Wei
Li, Jiao
E, Heng-Chao
Liu, Bao-Shu
Tang, Hua
Gerwick, William H.
Hua, Hui-Ming
Zhang, Wen
Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title_full Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title_fullStr Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title_full_unstemmed Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title_short Briarane Diterpenes from the South China Sea Gorgonian Coral, Junceella gemmacea
title_sort briarane diterpenes from the south china sea gorgonian coral, junceella gemmacea
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944505/
https://www.ncbi.nlm.nih.gov/pubmed/24473165
http://dx.doi.org/10.3390/md12020589
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