Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1–6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were...

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Autores principales: Sun, Zhang-Hua, Cai, Ying-Hong, Fan, Cheng-Qi, Tang, Gui-Hua, Luo, Hai-Bin, Yin, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944508/
https://www.ncbi.nlm.nih.gov/pubmed/24473168
http://dx.doi.org/10.3390/md12020672
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author Sun, Zhang-Hua
Cai, Ying-Hong
Fan, Cheng-Qi
Tang, Gui-Hua
Luo, Hai-Bin
Yin, Sheng
author_facet Sun, Zhang-Hua
Cai, Ying-Hong
Fan, Cheng-Qi
Tang, Gui-Hua
Luo, Hai-Bin
Yin, Sheng
author_sort Sun, Zhang-Hua
collection PubMed
description Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1–6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1–6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC(50) values of 8.5 and 20.3 µM, respectively.
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spelling pubmed-39445082014-03-07 Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo Sun, Zhang-Hua Cai, Ying-Hong Fan, Cheng-Qi Tang, Gui-Hua Luo, Hai-Bin Yin, Sheng Mar Drugs Six new tetraprenylated alkaloids, designated as malonganenones L–Q (1–6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1–6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1–6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC(50) values of 8.5 and 20.3 µM, respectively. MDPI 2014-01-27 /pmc/articles/PMC3944508/ /pubmed/24473168 http://dx.doi.org/10.3390/md12020672 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Sun, Zhang-Hua
Cai, Ying-Hong
Fan, Cheng-Qi
Tang, Gui-Hua
Luo, Hai-Bin
Yin, Sheng
Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title_full Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title_fullStr Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title_full_unstemmed Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title_short Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo
title_sort six new tetraprenylated alkaloids from the south china sea gorgonian echinogorgia pseudossapo
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944508/
https://www.ncbi.nlm.nih.gov/pubmed/24473168
http://dx.doi.org/10.3390/md12020672
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